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16 Cards in this Set
- Front
- Back
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Foscarnet - Clinical Use
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Herpetic Infection: HSV, CMV, Varicella Zoster (those who are refractory to Acyclovir)
HIV Infections |
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Foscarnet - adverse effects
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nephrotoxicity
hypocalcemia |
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Foscarnet - structure
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mimics inorganic pyrophosphate
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AZT/Zidovudine
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Prodrug: requires activation to triphosphate form which inhibits viral reverse transcriptase; incorporation into the viral nucleic acid leads to chain termination
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AZT/Zidovudine - adverse effects
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Bone Marrow Suppression
Mitochondrial Syndrome (lactic acidosis) |
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Nevirapine
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Non-nucleoside reverse transcriptase inhibitor
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Nevirapine - HIV 1 vs HIV 2
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active against HIV 1 but not HIV 2
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Nevirapine - drug interaction
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can increase the hepatic metabolism of other drugs (has phenobarbital like effect)
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Ritonavir
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Protease Inhibitor - peptidomimetic drug that inhibits HIV encoded aspartate protease
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Ritonavir - adverse effects
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lipodystrophy
drug interaction: can inhibit the metabolism of other drugs |
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Mechanism of Parasite Immune Evasion
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Antigenic Variation
Masked or shared host antigens Intracellular Sites Immunosuppression |
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Chlorquine
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Heme polymerization
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Mebendazole
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Mechanism by affecting the microtubules
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Trimethoprim/Sulfamethoxazole (
Septra) |
inhibits folate synthesis pathway
useful in treating pneumocystis jirovecii (carinii) pneumonia (opportunistic fungal pathogen) |
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Metronidazole
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selectively activated in anaerobes
reactive intermediate fragments the DNA |
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Metronidazole (other use)
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Disulfiram like effect - inhibits metabolism of alcohol
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