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108 Cards in this Set

  • Front
  • Back
Amantadine - contraindications
Renal impairment, chf, orthostatic hypotension, edema, sz disorder, psychosis, dermatitis
Entacapone - action
Inhibits dopamine metabolism
Barbituartes - adverse affects
Sedation, dizziness, lethargy, cognitive impairment, behavioral changes, tolerance, dependence, dermatitis, Stevens Johnson's Syndrome

anamtadine - clinical uses
Parkinsons, influenza A prophylaxis and tx.
SSRI - contraindications
within 14 days of MAOI use. Avoid abrupt withdrawal. Impaired renal or liver function. Suicidal pts.
Hydantions - Mechanism of action
INhibits and stabilizes electrical discharges. Raises sz threshold.
Pramipexole - adverse affects
Dizziness, somnolence, drowsiness, hallucinations, hypotension
Bromocriptine - clinical uses
Parkinson's, hyperprolactinemia, acromegaly
Barbiturates - Clinical uses
sz, status epilepticus, febrile sz, sedative
Pramipexole - clinical uses
Entacapone - drug interactions
Dobutamine, methyldopa, isoproterenol, TCA's, MAOI's, sedatives, dopamine antagonists, erythromycin, ampicillin, cholestyramine
SSRi pharmacokinetics
Thoroughly absorbed PO. Metabolized in liver. Excreted via kidneys. Onset of respones = 3-6 weeks. Long 1/2 life.
Succinimides - clinical uses
absence sz - DOC
Barbiturates - drug interactions
Cytochrome P450 enzyme involvement. CNS depressants, acetaminophen, anticoagulants, OCP, TCA's, antibiotics
Amantadine - side effects
Dizziness, anxiety, impaired coordination, restlessness, irritability, confusion, hellucinations, depression, orthostatis hypotension, edema, enaorxia, xerostomia
Succinimides - contraindications
Pregnancy class C. Lactation, liver problems, blood dyscrasias
Tolcapone - contraindications
Driving, hepatic disease, hypotension, sycnope, diarrhea, hematuria
Succinimides - adverse affects
N&V, lethargy, sedation, dizziness
Benzodiazepine - mechanism of action
Increase action of GABA, decreasing the effect of neuronal excitation.
Succinimides - drug interactions
CNS depressants, etoh, hydantoins, OCP
Pramapexole - Drug interactions
Dopamine antagonists, cimetidine
SSRI - mechanism of action
Selective action against serotonin pump (5ht transporter). Blocks reuptake of serotonin
Pramipexole - contraindications
Caution while driving. Caution with hypotension and renal insufficiency
Entacapone - clinical uses
Barbiturates - contraindications
Pregnancy class D. Renal and liver failure, heart problems, chronic respiratory disease
Stimulants - Clinical uses
Succinimides - example
Hydantions - adverse effects
Gingival hyperplasia, nystagmus, confusion, hirsutism, hypotension, neuropathy, sedation, teratogenesis
Ropinirole - actions
Stimulates dopamine receptors. Non-ergot dopamine agonist that acts on D2 and D3 receptors
Bromocriptine - action
Stimulates dopamine receptors - ergot alkaloid that is a D2 agonist. Growth hormone stimulant.
Entacapone - adverse affects
Dizziness, sedation, confusion, hallucinations, diarrhea, abd pain, hypotension, syncope, hematuria, elevated hepatic enzymes
Benzodiazepines - examples
Diazepam, clonazepam, lorazepam, chlordiazepoxide
Hydantions - Uses
Sz, Prophylaxis for status epilepticus, arrythmias
Ropinirole - drug interactions
Cimetidine, cipro, clarithromycin, diltiazem, erythromycin, fluvoxamine, omeprazole, ritonavir, carbamezepine, phenobarb, dilantin, dopamine antagonists
Valproates - adverse affects
N&V, weight gain, sedation, ataxia, tremor, hepatotoxicity
Benzodiazepines - clinical uses
Status epilepticus (diazepam is DOC), absence sz, acute etoh withdrawal, anxiety (short term)
Ropinirole - clinical uses
Benzodiazepines - adverse affects
Drowsiness, lethargy, respiratory and cardiovascular depression
Stimulants - contraindications
Pregnancy, lactation, glaucoma, Tourette's syndrome, anxiety, MAOI, CV disease, hypertension, sz, hyperthyroidism, alcohol/drug abuse
Bromocriptine - adverse affects
Hypotension, confusion, hallucinations, dyskinesias, N&V, constipation, anorexia
SSRI - clinical uses
Depression, OCD, bulimia nervosa, panic, anxiety, PTSD, premenstrual dysphoric disorder
stimulants - drug interactions
MAOI's (hypertensive reaction), SSRI (increase serum concentration of SSRI's)
Benzodiazepines - contraindications
Pregnancy, lactation, hepatic and renal disease, acute closed angle glaucoma, dependancy
Benzodiazepines - drug interactions
CNS depressants, barbiturates, etoh, antihistamines, neuroleptics, TCA's, digitalis
Hydantions - Examples
Phenytoin, fosphenytoin
Ropinirole - adverse affects
Diaphoresis, flushing, xerostomia, dizziness, drowsiness, hyperesthesia, restlessness, vertigo, hypotension, a-fib, s. tach, syncope, abd pain, flatulence
Succinimides - mechanism of action
Suppression of motor cortex, inhibition of stimuli. Decreases sz threshold.

Hydantions - Drug interactions
Cytochrome P450 enzyme involvement. Tagamet, antabuse, etoh, salicylates, valporic acid, rifampin, antacids, tegretol, estrogens, haldol, steroids, dopamine, lasix
SSRI - drug interactions
Other sertonergics, ergotamine, MAOI's, valporate, carbamazepine, TCA's, benzodiazepines
Bromocriptine - drug interactions
CYP3A4 enzyme substrate agents (erythromycin, protease inhibitors), amiutryptiline, imipramine, methyldopa, phenothiazines, reseprine, ergot alkaloids
Valproates - examples
Valporic acid (depakote, depacon)
SSRI adverse affects
Serotonin syndrome (N&V, diarrhea, chills, sweating, hyperthermia, hypertension, cyocolinc herking, agitation, ataxia, disorientation, cofusion, delium - leads to coma or death).. Common affects - insominia, H/a, fatifue, anorexia, decreased libido, delayed ejacuation, impotence
Hydantions - contraindications
Pregnancy category C. Cardiad problems, hypotension, liver damage
Valproates - mechanism of action
Increases action of GABA
Entacapone - contraindications
Driving, hepatic disease, hypotension, sycnope
Valproates - clinical uses
Absence, mixed, myoclonic, generalized sz, bipolar disorder
Levo/carbodopa - clinical uses
Valproates - drug interactions
Phenobarb, phenytoin, carbamazepine, CNS depressants
SSRI - class
Valproates - contraindications
Pregnancy class D (associated with spina bifida), liver disease, bleeding disorders, renal impairment.
Tolcapone - drug interactions
dobutamine, methyldopa, isoproterenol, TCA's, MAOI's, sedatives, dopamine antagonists
MAOI - examples
Nardil, parnate
TCA- class
ropinirole - contraindications
Caution with driving. Syncope, hypotension, hepatic disease, psychosis
Stimulants - examples
Dextroamphetamine (dexedrine, adderall)
What are the three things anti-parkinson drugs do?
1. Increase dopamine levels (levodopa plus carbidopa)
2. Stimulate dopamine receptors (bromocriptine, pergolide, pramipexole, ropinirole)
3. Inhibit dopamine metabolism (selegiline, topcapone, entacapone)
Selegiline - clinical uses
Pergolide - action
Stimulates dopamine recpetors. Semi-synthetic ergot alkaloid. D1 and D2 agonist. 10x more powerful than bromocriptine.
Barbiturates - mechanism of action
Ingibits GABA receptors. Causes membrane hyperpolarization, and decrease in neuronal excitability. Increases sz thershold.
TCA - examples
amitriptyline, clomapramine, imipramine, protriptyline, desipramine, doxepin, nortriptyline, trimipramine
Pergolide - clinical uses
Selegiline - action
Inhibits dopamie metabolism. Non-competetive antagonist of MAO type B (oxidizes dopamine in the brain)
TCA - uses
depression, ocd, enuresis in kids, anxiety, chronic pain
MAOI - class
TCA - mechanism of action
Blocks serotonin and norepi reuptake pumps. BLocks muscarinic cholinergic, histamine and alpha 1 adrenergic receptors
TCA - phramacokinetics
Thoroughly absorbed PO. Metabolized in liver excreted via kidneys. 1/2 life average = 24-36 hours. 2-4 weeks before remission of symptoms
TCA - drug interactions
CNS depressants, SSRI's, Ca channel blockers, propoxyphens, OCP, anticholinergics, carbamazepine, phenytoin, MAOI's, clonidine, cannabis
TCA - adverse affects
dry mouth, constipation, weight gain, urinary hesitancy, gynecomastia, libido changes, hypotension, sedation
Stimulants - mechanism of action
Prevents reuptake of dopamine, serotonin, and norepi in the presynaptic nerve endings. Stimulates the brain stem and cerebral cortex.
Seligiline - drug interactions
MAOI's, TCA's, fluoxetine, SSRI's, meperidine, serotonin receptor agopnists, COP, tramadol, tyramine
Selegiline - adverse affects
Confusion, hallucinations, loss of balance, insomnia, dyskinesia, labile emotions, hypotension, cyncope, dysphagia, dyspepsia, peripheral edema, urinary retention
Levodopa plus carbidopa - action
Increases dopamine levels. Rapidly converts to dopamine in PNS and CNS. Crosses blood brain barrier.
TCA - contraindications
cardiovascular disease (recent MI), glaucoma, prostate hypertrophy, MAOI's, pregnancy, sz, impaired liver function. Caution with children, elderly and suicidal pts, even more so than with SSRI's
SSRI - examples
prozac, sarafem, paxil celexa, zoloft, luvox, lexapro
Levo/carbodopa - side effects
Anorexia, N&V, constipation, dyskinesia, involuntary movements, tachycardia, orthostatic hypotension, arrythmias, confusion, nightmares, anxiety
Barbiturates - examples
Pergolide - drug interactions
Dopamine antagonists, phenothiazines, droperidol, metoclopramide
MAOI - adverse affects
Abrupt discontinuation - withdrawal. Insomnia, anxiety, agitation, dryu mouth, urinary retention, decreased sexual function.
Amantadine - drug interactions
Dopamine antagonists, anticholinergics, TCA, sedating anti-histamines, triamterine, hctz
MAOI - mechanism of action
inhibits MAO which metabolizes norepi, serotonin and dopamine. This increases bioavailabity of these neurotransmitters
MAOI - phramacokinetics
rapidly and thoroughlly absorbed PO. Metabolized i liver and excreted via urine. Relief of symptoms in 14 days.
Levo/carbidopa - drug interactions
Pyridoxine (vitamin B-6), dopamine antagonists, MAOI's
MAOI - clinical uses
Not commony used due to drug interactions and side effects. Can be used for refractory unipolar dipression, bulimia.
Pergolide - adverse affects
Diskinesias, dystonic reactions, hallucinations, drowsiness, anxiety, insomnia, hypotension, palpitations, abd pain, constipation, anorexia
Stimulants - pharmacokinetics
Metabolized in the liver, excreted in kidneys
Amantadine - action
Increases dopamine levels. Anti-viral agent that blocks dopamine uptake
Bromocriptine - contraindications
Severe ischemic heart dis4ease, peripheral vascular disorders, pregnancy
Stimulants - adverse affects
Insominia, restlessness, irritability, euphoria, h/z, dizziness, anorexia, abd pain, weight loss, tachycardia, blood pressure changes, growth supression (temporary)
Pramipexole - actions
Stimulates dopamine receptors. Non-ergot dopamine agonist that binds to D2 and D3 receptors in the substantia nigra
Stimulants - examples
Methylphenidate (ritalin, methylin, metadata, concerta)
Tolcapone - adverse affects
Dizziness, sedation, confusion, hallucination, diarrhea, anorexia, hypotension, syncope, hematuria, elevated hepatic enzymes
MAOI - drug interactions
Anticholinergics, sympathomimetics, stimulants, foods with tyramine, SSRI's, CNS depressants, antihypertensives, diuretics, meperidine, TCA"s, OTC cold medicines
Levo/carbidopa - contraindications
Glaucoma, MI, arrythmias, astham, PUD
Pergolide - contraindications
Seligiline - contraincications
PUD, dementia, tardive dyskinesia
Tolcapone - actions
Inhibits dopamine metabolism. Selective and revensibke ingibitor of catechol-o-methyltrnasferase (metabolizes catecholamines). Leads to sustained plasma levels of levodopa to cross into CNS
Tolcapone - clinical uses
MAOI - contraindications
Liver and kidney disease, CHF, atherosclerotic disease, >60 y/o, SSRI use, buproprion use, general anesthesia, children, pregnancy category C