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12 Cards in this Set

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how do you adjust for first pass metabolism?
increase the dose
what types of drugs are easily absorbed in the stomach?
lipid soluble drugs and weak acids
what is the bioavailability of drug for intravenous administration?
1 (full bioavailability)
what are barriers to bioavailability in the oral route of administration?
first pass metabolism by the liver, gastric contents, intestinal motility, metabolism by enterocytes, blood flow, stomach acid, and interactions with foods and other drugs.
what does a high volume distribution mean?
The drug is mainly distributed in the tissues, not in the plasma
define clearance mathematically and conceptually.
CL is measure of the cody's capacity to remove a drug. Mathematically it is the proportionality constant that relates rate of elimination of drug to the plasma concentration. Its units are vol/time
What is the main difference between first order and zero order kinetics?
first order rate of elimination depends upon clearance while zero order does not (rate of elimination is constant)
In implementing a new steady state concentration, what rule holds true for first order elimination?
Css(old)/Css(new) =

old dose/new dose
Is clearance dependant upon half life, bioavailability or volume distribution?
NO!!
how do you calculate a loading dose?
loading dose = CpxVd/F
half life depends on what two factors?
CL and Vd
what are some factors that lead to altered absorption and disposition in the eldery?
decreased gastric acid, decreased lean body mass, increased percentages of body fat, decreased liver mass and blood flow, and reduced renal function