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13 Cards in this Set
- Front
- Back
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Important binding proteins
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albumin
•Acid glycoproteins |
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name 3 drugs that bind to albumin |
phenytoin,salicylates, and disopyramide are extensively bound to plasma albumin
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which drugs bind to Alpha1-acid glycoprotein
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drugssuch as quinidine, lidocaine, and propranolol
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>90% bound drugs
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lSalicylates, Phenytoin, Warfarin, Tiagabine, Valproic Acid, Stiripentol, Tolbutamide
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•Phase 1 reactions
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–Provide a more chemically reactivegroup to increase polarity of the drug molecule and a site for phase 2metabolism
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Oxidative metabolism
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Microsomal Cytochrome P450 (CYP)
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•;the most abundantly expressed and involved in the metabolism of about 50% ofclinically used drugs
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CYP3A4
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Carbamazepine (anticonvulsant)
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Potent enzyme inducer(стимуляция) and exhibits autoinduction
1)Metabolisedby CYP3A4 ~ |
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name metabolized Fosphenytoin
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–Phenytoin (antiepylepyic)
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Enalapril
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Enalaprila (decrease bp)
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Paracetamol
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N-acetyl-p-benzoquinonimin
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Eslicarbazepineacetate
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Eslicarbazepine
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at which half life drug will be eliminated by 95% |
4-5 |
