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39 Cards in this Set
- Front
- Back
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Irreversible condition resulting from use of antipsychotics, reserpine at high doses, MPTP
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Drug induced parkinsons
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Agent used in drug therapy of Parkinson's instead of Dopamine which has a low bioavailability and does not cross the BBB
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L-dopa
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This is combined with L-dopa, inhibits DOPA decarboxylase which allows lower effective doses of Ldopa and allows for fewer SEs (GI distress, postural hypotension, dyskinesias)
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Carbidopa
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Clinical response that may fluctuate in tx of Parkisnons
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On-Off phenomenon
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Antiparkinsons drug which increases intraocular pressure and is contraindicated in closed angle glaucoma
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L-dopa
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Ergot alkaloid that is a partial agonist at D2 receptors in the brain, used for patients who are refractory or cannot tolerate levodopa, causes erythromelalgia
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Bromocriptine
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Nonergot agents used as first line therapy in the initial management of Parkinson's
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Pramipexole
Ropinirole |
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Enhances dopaminergic neurotransmission SEs inlcude CNS excitation, acute toxic psychosis and livedo reticularis
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Amantadine
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Inhibitor of MAO-b which slows down metabolism of dopamine, used adjunct to levodopa or as sole agent in newly diagnosed patients
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Selegiline
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Inhibitors of COMT used as adjuncts in Parkinson's Dz and cause acute hepatic failure (monitor LFTs)
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Tolcapone
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Agent decreases the excitatory actions of cholinergic neurons. May improve tremor and rigidity but have LITTLE effect on bradykinesia. Atropine-like SEs
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Benzotropine
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Agent effective in physiologic and essential tremor
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Propranolol
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Agent used in Huntington's Dz
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Tetrabeazine (amine depleting drug),
Reserpine |
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Agent used in Tourette's dx
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Haloperidol
Pimozide Clonidine |
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Chelating agent used in Wilson's Disease
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Penicillamine
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signs of Parkinson's
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RAFT
rigidity Akinesia (dyskinesia) Flat facies tremor |
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DOC RLS
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Ropinirole
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Drugs useful in acute dystonias
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Benzotropine
Diphenhydramine |
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Antipsychotics which induce parkinsonism
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Butyrophenone
Phenothiazine |
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Dopamine receptor subtype targeted in Parkinsons
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D2
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Apomorphine function in Parkinsons?
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can reduce off times
COMTs DOC for reducing fluctuations |
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Common SEs for Levodopa
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Dyskinesias (limiting SE)
Emesis (D2) Hypotension (D1) Decreased Prolactin |
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Levodopa is contraindicated in patients which a history of ______
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psychosis
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Drug causing Erythomelalgia and Pulmonary infiltrates
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Bromocriptine
erythromelalgia is red tender swelling, usually of feet |
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D3 receptor agonist administered 3x daily, must monitor renal function
contraindicated in? |
Pramipexole
PUD Psychotic illness recent MI |
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D2 receptor agonist used to smooth out fluctuations
reduced clearance with coadministration with caffeine/warafin |
Ropinirole
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rapid treatment of off periods
requires 3d pretreatment of antiemetics |
apomorphine
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drugs to be avoided with use of Selegiline
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Meperidine
SSRIs |
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Why does selegiline cause insomnia
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metabolized to amphetamines
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Parkinson's drug causing orange urine
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Entacapone
Tolcapone |
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Toxic effect of Amantadine
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Livedo Reticularis (net-like skin rash)
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Benzotropine/Trihexyphenidyl have no effects on
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bradykinesia
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ß blocker used for tremor with concomitant pulmonary disease
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metoprolol
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DOC Tourette's
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Haloperidol
reserpine tetrabenazine |
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DOC Wilson's
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Penicillamine
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DOC RLS
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Ropinirole
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possible dopamine effects on eye
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mydriasis and triggering an attack of acute glaucoma
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Drugs ameliorative of Huntington's symptoms
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Haloperidol (blocks dopaminergic receptors)
Tetrabenazine (depletes dopamine) |
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DOC to prevent toxicity of MPTP
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Selegiline
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