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20 Cards in this Set

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vancomycin
bacitracin
What are the specific glycopeptides?
Because it has no beta lactam structure.
Can use in resistant hospital based infections.
For colitis
Why use a glycopeptide?
Major toxicity limits systemic use except in resistant hospital based infections.
Why shouldn't you use a glycopeptide?
Vancomycin
_________ may be a drug of choice for some types of colitis because it does not absorb well and remains in the intestines.
Bacitracin
______ is chiefly a topical agent because of its toxicity.
Aminoglycosides
For serious aerobic gram - infections

Broad spectrum

Must be used parenterally unless for GI parasites as when treating hepatic coma or prior to bowel surgery (not absorbed orally).

Does NOT cross the BBB adequately.

Will work intracellularly but has trouble penetrating.

Caution: otoxicity and renal damage
Aminoglycosides including streptomycin
For serious aerobic gram - infections

for tuberculosis
Broad spectrum
What is the spectrum of Aminoglycosides?
Protein synthesis inhibitors
What is the mech of action for Aminoglycosides?
Aminoglycosides
Streptomycin is part of the this group?
otoxicity and renal damage

hearing loss (may be irreversible)
What are the side effects of Aminoglycosides?
DNA inhibitors or prevent bacterial DNA from replicating.
What is the mech of action for Quinolones/Floroquinolones?
broad spectrum
What is the spectrum for Quinolones/Floroquinolones?
*** Cartilage and tendon erosion in young dogs and rats explains contraindications in pregnant or nursing women or in children under 18.

nausea
anaphylaxid
rashes
visual disturbances
phototoxicity
depressed bone marrow
acute interstitial nephritis
arthritis
tendonitis
What are the adverse effects of taking Quinolones/Floroquinolones?
adverse effects of taking Quinolones/Floroquinolones
*** Cartilage and tendon erosion in young dogs and rats explains contraindications in pregnant or nursing women or in children under 18.

nausea
anaphylaxid
rashes
visual disturbances
phototoxicity
depressed bone marrow
acute interstitial nephritis
arthritis
tendonitis


What drug?
Macrolides including erythromycin
inhibits protein synthesis

spectrum sim. to penicillin
(narrow spectrum)

resistant strain develop easily

allergic reactions may occur and GI side effects are common.

Otherwise low toxicity
Macrolides including erythromycin

Lincosamides
Protein synthesis inhibitor

Use this when patients are allergic to pencillin.
Tetracycline
decrease the effectiveness of oral contraceptives

broad spectrum

Not a fungi, but may permanently discolor children's teeth if used from fourth month of fetal life though eight year of childhood.

Photosensitivity (use sunscreen)

Superinfection a problem with chronic therapy (acne).

need food in stomach but not milk or antacids.
Not a fungi, but may permanently discolor children's teeth if used from fourth month of fetal life though eight year of childhood.

Photosensitivity (use sunscreen)

Superinfection a problem with chronic therapy (acne).
What are the side effects of tetracycline?
Lincosamides
specifically for anaerobic bacteria

causes colitis

can be used if allergic to penicillin if other less toxic alternatives don't work.