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24 Cards in this Set

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salicylates
aka aspirin
aniline derivatives
aka acetaminophen or Tylenol
NSAID
aka Ibuprofen or Motrin
salicylates

therapeutic
salicylate or aniline derivative?

therapeutic, side or toxic, or chronic toxic effect?

Relief of pain - headache, dysmenoreehea, ARTHRITIS
salicylates and aniline derivatives

therapeutic
salicylate or aniline derivative?

therapeutic, side or toxic, or chronic toxic effect?

Antipyretic - decreases fever
salicylates

therapeutic
salicylate or aniline derivative?

therapeutic, side or toxic, or chronic toxic effect?

Antiinflammatory
a. Rheumatoid arthritis
b. Rheumatic fever - decreases scarring of heart valve
salicylates

therapeutic
salicylate or aniline derivative?

therapeutic, side or toxic, or chronic toxic effect?

Anticoagulant effect for venous or coronary thrombosis. Now approved for after myocardial infarction and to help prevent stroke.
aniline derivatives

therapeutic
salicylate or aniline derivative?

therapeutic, side or toxic, or chronic toxic effect?

Relief of pain - headache, dysmenorrhea
salicylates

acute side effects or toxicities
salicylate or aniline derivative?

therapeutic, side or toxic, or chronic toxic effect?

GI irritation and decreased coagulation (bleeding) with continued use, gastric mucosa usually heals in 3 days. Caution: black stools.
salicylates

acute side effects or toxicities
salicylate or aniline derivative?

therapeutic, side or toxic, or chronic toxic effect?

CNS stimulation

Respiratory stimulation to point of respiratory alkalosis.
salicylates

Chronic toxicities
salicylate or aniline derivative?

therapeutic, side or toxic, or chronic toxic effect?

Hearing - ringing in ears, hearing loss (reversible), dizziness (inhibits enzyme in the cochlea)
salicylates

Chronic toxicities
salicylate or aniline derivative?

therapeutic, side or toxic, or chronic toxic effect?

Possible slight decrease in GFR, negligible compared to phenacetin or even acetaminophen toxicity. No significant liver damage. Caution: if patient already has liver or kidney damage.
aniline derivatives

Chronic toxicities
salicylate or aniline derivative?

therapeutic, side or toxic, or chronic toxic effect?

Kidney or liver damage. In fact, irreversible liver damage with one overdose of acetaminophen.
aniline derivatives

Chronic toxicities
salicylate or aniline derivative?

therapeutic, side or toxic, or chronic toxic effect?

Blood disease - anemia
aniline derivatives

Chronic toxicities
salicylate or aniline derivative?

therapeutic, side or toxic, or chronic toxic effect?

Possible link to bladder cancer
Reyes Syndrome
A rare, life-threatnening condition associated with viral infection and characterized by hepatic injury, vomiting, lethargy, and belligerence that may progress to delirium and coma. Mortality rate is 20% - 30%. Permanent brain damage has been reported in survivors. Note: although no causal relationship with salicylates has benn established, many agencies including the surgeon general and the FDA advise against the use of salicylates in children (including teenagers) with influenza or chicken pox.
NSAID
What are the prostaglandin-inhibitor analgesics that are used to treat Rheumatoid Arthritis?
NSAID
Works better than aspirin in Arthritis.

much more expensive.
Prostaglandins
deactivated
stimulus
___________ are a group of fatty acid derivatives exhibiting a variety of physiological activities. They chiefly affect biological processes near their point of release and are _________ at or near their locus of release. Generally they function as essential intermediates btwn a given __________ and its cellular response.
arachiodonic
inflammatory
anti-inflammatory
antiplatelet
One enzyme involved in prostaglandin production from _________ acid is cyclooxygenase (COX). Two forms of this enzyme, called isoenzymes, are COX-1 (in all tissues) and COX-2 (inducible by __________ stimuli and notably absent from GI tissues). Current thought is that COX-2 inhibitors permit pain relief and ______________ effects while minimizing GI side effects. They do not have _________ effects.
Steroids
What is the "other" treatment for rheumatoid arthritis besides NSAIDS or aspirin?
Salicylates
NSAIDs
COX 2 inhibitors
steriods
What are ALL of the choices that we need to know to treat rheumatoid arthritis?
COX 2 inhibitor
What is Celebrex?
COX 2 inhibitors
These all work in the SAME manner as ASPIRIN, with the same side effects, and none is generally better than aspirin. ALL are MUCH more expensive than aspirin. Individual patients may get better relief with one drug or another. Several of the above are a bit more gentle on the stomach but they also seem to be more toxic to the LIVER, KIDNEYS, and BONE MARROW.

What drug?