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27 Cards in this Set

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Atropine
Scopolamine
What are the 2 drugs of choice that inhibit cholinergic effects?
Therapeutic uses (cholinergic antagonist drugs)
1. GI (antimuscarinic)
2. Relaxation of bladder
3. Opthalmic uses
4. Treatment of cholinergic toxicity
5. Preanesthetic medication
6. skeletal muscle relaxants
1. GI (antimuscarinic)
a. peptic ulcer
b. decreasing cramps or diarrhea
c. acute pancreatitis
Relaxation of bladder
(relieves pain of inflammation)(antimuscarinic)
3. Opthalmic uses
(antimuscarinic) - contraindicated in glaucoma
a. dilation of eye examination (adrenergic drugs safer), or to prevent adhesions to lens
b. inhibits accommodation for near vision - eye exam without focusing interface
4. Treatment of cholinergic toxicity
most common situation: give antimuscarinic drug with a nicotinic agonist (in order to stimulate skeletal muscle but block parasympathetic side effects)
5. Preanesthetic medication
reduced secretions (antimuscarinic effect)

In general, not good for asthma, because secretion become too dry and obstructive - however, ipratropium (atrovent) an anti-cholinergic agent is being used as a bronchodilator with encouraging results esp. when used with a b2 agonist.
1. GI (antimuscarinic)
2. Relaxation of bladder
3. Opthalmic uses
4. Treatment of cholinergic toxicity
5. Preanesthetic medication
6. skeletal muscle relaxants
What are the 6 therapeutic uses for drugs that inhibit cholinergic effects?
1. dry mouth
2. urinary retention (esp. in older men)
3. blurred vision
4. dizziness and fatigue
What are the 4 side effects for drugs that inhibit cholinergic effects?
antimuscarinic
What kind of inhibiting cholinergic side effect is this?

Dry mouth
antimuscarinic
What kind of inhibiting cholinergic side effect is this?

urinary retention (esp in older men)
antimuscarinic
What kind of inhibiting cholinergic side effect is this?

blurred vision
CNS effect
What kind of inhibiting cholinergic side effect is this?

dizziness and fatigue
1. pupillary dilation - photophobia
2. Dry mouth, constipation
3. Increased body temp (decreased sweat)
4. palpitations
5. Behavioral changes(sedation; confusion, esp in elderly)
6. Respiratory depression
What are the 6 toxic effects that may occur with drugs that inhibit cholinergic effects?
antimuscarinic
pupillary dilation - photophobia

What type of cholinergic drug does this toxic effect?
antimuscarinic
Dry mouth, constipation

What type of inhibiting cholinergic drug has this toxic effect?
antimuscarinic
Increased body temp (decreased sweat)

What type of inhibiting cholinergic drug has this toxic effect?
CNS effect
Behavioral changes(sedation; confusion, esp in elderly)


What type of inhibiting cholinergic drug has this toxic effect?
antinicotinic
Respiratory depression

What type of inhibiting cholinergic drug has this toxic effect?
Glaucoma
Gastric or urinary retention
What are the contraindications from taking drugs that inhibit cholinergic effects?
antimuscarinic
What type of cholinergic drug may have contraindication, Glaucoma?
antimuscarinic
What type of cholinergic drug may have contraindication, gastric or urinary retention?
a. facilitate surgery
b. facilitate electroconvulsive therapy
c. facilitate endotracheal intubation
d. treat tetanus
What are the therapeutic uses for skeletal muscle relaxants on the periNS?
therapeutic uses for skeletal muscle relaxants on the periNS
a. facilitate surgery
b. facilitate electroconvulsive therapy
c. facilitate endotracheal intubation
d. treat tetanus
surgery
endotracheal
a. facilitate _______
b. facilitate electroconvulsive therapy
c. facilitate ____________ intubation
d. treat tetanus
cautions for skeletal muscle relaxants on the periNS
a. may cause respiratory paralysis
b. may cause cardiac collapse (antinicotinic effect drops BP)
c. interactions with other drugs alter the neuromuscular blocking action.
1. activity increases with many antibiotics (streptomycin) and antiarrhythmics (quinidine( and acidosis.
2. neuromuscular blocking action decreases with low serum potassium
d. better absorption of many other drugs due to slower GI motility. May result in toxicities.
respiratory
neuromuscular
increases
decreases
toxicities
a. may cause __________ paralysis
b. may cause cardiac collapse (antinicotinic effect drops BP)
c. interactions with other drugs alter the __________ blocking action.
1. activity __________ with many antibiotics (streptomycin) and antiarrhythmics (quinidine( and acidosis.
2. neuromuscular blocking action __________ with low serum potassium
d. better absorption of many other drugs due to slower GI motility. May result in __________.