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13 Cards in this Set

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Normal function of the synapse.
1. stimulation of neuron #B or effector organ.
2. Removal of the stimulation of neuron #B or effector.
Depending on transmitter substance, stimulation may be stopped by the:

a. use of an enzyme to destroy the transmitter (Acetylcholine destroyed by cholinesterase-important)
b. reuptake of the transmitter into neuron #A (Norepinephrine - most important removal mechanism) (much less significant for ACE)
1. stimulation of neuron #B or effector organ.
2. Removal of the stimulation of neuron #B or effector.
What is the normal function of the synapse?
it depends on what neurotransmitter it is.
What does the removal of the stimulation of neuron #B or effector depend on?
a. use of an enzyme to destroy the transmitter
b. reuptake of the transmitter into neuron #A
Depending on transmitter substance at the synapse, how can the stimulation be stopped?
cholinesterase
What enzyme destroys the neurotransmitter, Acetylcholine?
reuptake of the transmitter into neuron A.
What process is the most important removal mechanism for NE at the synapse?
effector
stimulation
stopped

enzyme
cholinesterase
reuptake
Norepinephrine
1. stimulation of neuron #B or _________ organ.
2. Removal of the __________ of neuron #B or effector.
Depending on transmitter substance, stimulation may be _________ by the:

a. use of an ________ to destroy the transmitter (Acetylcholine destroyed by ____________ -important)
b. ________ of the transmitter into neuron #A (____________- most important removal mechanism) (much less significant for ACE)
a. receptor agonist acts a transmitter themselves by combining with the receptor.

b. stimulate the release of the 1st neuron's transmitter substance.

c. inhibit or block the removal of the body's natural transmitter substance (cholinesterase inhibitors)
How does the receptor AGONIST
(the drug which stimulates) alter normal synapse function?
agonist

stimulate

removal
a. receptor _______ acts a transmitter themselves by combining with the receptor.

b. _________ the release of the 1st neuron's transmitter substance.

c. inhibit or block the ________ of the body's natural transmitter substance (cholinesterase inhibitors)
Receptor antagonist blocks receptor sites so they can't be stimulated.

This in turn, blocks the release of body's own transmitter substance.
How does the receptor ANTAGONIST
(the drug which inhibits) alter normal synapse function?
antagonist
transmitter
Receptor __________ blocks receptor sites so they can't be stimulated.

This in turn, blocks the release of body's own __________ substance.
Cholinergic
__________ receptors (Muscarinic and Nicotinic) respond to Acetylcholine.
Adenergic
__________ receptors (alpha, b1, b2) respond to Norepinephrine.