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24 Cards in this Set

  • Front
  • Back
What is synthroid?
Most common synthetic T4 therapy
What is Levothyroid?
Most common synthetic T4 therapy
What is the most common T4 therapy?
Synthroid or levothryoid
What is Liothyronine?
Most common T3 therapy
What is the most common T3 therapy?
Liothyronine
What is Liotrox?
A synthetic T3/T4 combo
What is the indication for Methimazole in pregnant women?
It is a synthesis inhibitor that crosses the placental barrier, so it is contraindicated
What is methimazole?
A thyroid hormone synthesis inhibitor
What is propylthiouracil (PTU)?
a protype synthesis inhibitor
which is more potent, propylthioruacil (PTU) or methimazole? longer half life.
Methimazole is 10-50x more potent. Methimazole.
What are thiocynate and perchlorate?
Ionic inhibitors of iodide transport
How might iodide be used therapeutically?
High concentrations inhibit release of thyroid hormones
What drug can be given in a smaller dose in smokers?
thiocyanate
What is Etidornate?
A mineralization inhibitor biphosphate
What is pamidronate?
Biphosphate
What are biphosphates used for?
hypercalcemia, paget's diease, osteoporosis
How do ionic inhibitors work? Name 2.
Interfere with the concentration of iodide by the thyroid gland. Thiocyanate and perchlorate
What is the Wolff-Chaikoff effect?
Iodide inhibits the synthesis of iodotyrosine and iodotyronines.
How do ionic inhibitors work? Name 2.
Interfere with the concentration of iodide by the thyroid gland. Thiocyanate and perchlorate
What is the Wolff-Chaikoff effect?
Iodide inhibits the synthesis of iodotyrosine and iodotyronines.
What is the MOA of bisphosphates?
Inhibit bone resorption by repressing osteoclast function.
What is the typical treatment regimen for osteoporosis?
Physical Activity
Proper dietary calcium
Vit D
CT
Bisphosphonates
Thiazides
Why do you use thiazides in osteoporosis?
Reduction of urinary calcium and limits bone loss in pts with hypercalciuria
What is cibacalcin?
Therapeutic Calcitonin