**pharm Test 3 - Lecture 5 - Type 2 Diabetes

Front 1

6 classes of oral type 2 drugs

Back 1

sulonylurea
biguanides
alph glucosidase
TZD
dipep-pep-IV-inhib
incretin mimetic

Front 2

3 ways that sulfonylureas work?

Back 2

increase release of insulin from beta cells
increase insulin release in glucose presence
increase insulin effect (more glucose uptake by muscle/fat cells)

Front 3

what is the difference between 1st and 2nd generation sulfonylureas?

Back 3

2nd is 10-100x more potenet

Front 4

metformin is of the ____class, and it is unique in that it is the )______

Back 4

biguanide
most prevalent type 2 oral drug

Front 5

4 mechanisms of metformin?

Back 5

inhibits glucose absorb
decrease hepatic glu output
improve insulin sensitivity
increases periph glu uptake/use

Front 6

alpha glucosidase inhibitor action?

Back 6

inhbiting the enzyme that breaks down carbs in the gut

Front 7

target of TZDs?

Back 7

PPAR-y

Front 8

how does TZD work?

Back 8

decrease insulin conc?
decfrease glu conc
increase insulin sensitivity

Front 9

TZD effect on fat?

Back 9

TZD keeps fat in fat tissues thereby increaseing insulin sensitivity of liver/msucle

Front 10

How do pioglitazone (actos) and rosiglitazone (avandia) work?

Back 10

decrease blood sugar by increasing sensitivity to insulin,
DOES NOT increae insulin release
decreases hepatic glucose output

Front 11

What does the enzyjme DPPIV do?

Back 11

breaks down incretin

Front 12

How does Januvia work?

Back 12

inhibits DPPIV, thereby prolonging effect of incretin, which helps pancreas make insuilin after we eat

Front 13

exenatide and pramlintide are ____Drugs. Exenatide is a ____analog, and Pramlintide is a ____analog, which is co-secreted with____.

Back 13

incretin mimetic
incretin analog
amylin
insulin