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41 Cards in this Set
- Front
- Back
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Estradiol is/is not degraded by GI tract. When giving ERT, you give it in the form of _____, which is modifiied by _____ at _____.
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IS degraded
ethinyl estradiol Ethinyl group C17 |
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What were the 2 benefits up to 90's of HRT?
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reduce menopausal symptoms
stave off bone loss |
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What form of estrogen is in premarin?
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conjugated equine estrogen
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What drugs contain conjugated equine estrogen?
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Premarin
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What form of estrogen is in estratab?
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esterified
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what effect does having an esterified estrogen in a drug have?
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reduces side effect, also reduces effectiveness
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What drugs contain esterified estrogen?
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estratab
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estraderm skin patches contain what form of estradiol?
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natrual estradiol
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what drugs contain natural estradiol?
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estraderm (transdermal patch/cream)
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What advantage does the drug prempro have?
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addition of progesterone, which decreases risk of endometrial hyperplasia (thus, cancer)
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what is the advantage of adding progesterone to an estrogen drug? whta drug has it?
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prempro has it
reduces risk of endometrial hyperplasia |
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what can reduce the risk of endometrial hyperplasia in estrogen drugs?
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addition of progesterone
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What is the use of prempro?(2)
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tx vsaomotor symptoms of menopause for women with intact uteri
prevent osteoporosis |
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what drug does this?
prevent osteoporosis tx of vasomotor symptoms of menopause in women with intact uteri |
prempro
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What 3 conclusions did the HERS study have? Who was studied?
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same amount of HD
Lower cholesterol more blood clots patients with HD who took estrogen |
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Subjects taking estrogen had
same amount of HD lower cholestreol more blood clots what study is this? |
HERS
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Nurses Health study concluced what 2 things?
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estrogen + progestin increases stroke
Bad outweights good of osteoporosis prevention |
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Study concluded that
estrogen + progestin increases risk of stroke, which outweights benefits of osteoporosis prevention what study is this? |
nurses health
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the Nurses health study concluded that estrogen + _____ increased risk of _____, so these _____be taken for the prevention of ______.
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progestin
stroke shouldn't osteoporosis |
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NIH prempro study concluded what 7 things?
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prempro increased....
HD, breast cancer, Stroke, Pulm embolism Prevented colorectal cancer, bone fracture Bad>good |
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What study showed that prempro increased risk of breast cancer, HD, pulmonary embolism and stroke, which outweights the good of preventing colorectal cancer and bone fractures?
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NIH prempro study
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the NIH prempro study showed the drug to increase risk of _____,____,_____ and _____. The drug prevents ____, and ____ and therefore _____be taken.
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cause HD, stroke, pulm embolism, breast cancer
bone fractures, colorectal cancer SHOULD NOT |
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What is the use of HRT today?
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short term use for tx of menopause symptoms like hot flashes, mood changes
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HRT is used today in the ____term, for tx of ___and ___ which are_____.
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short
hot flashes mood swings menopause symptoms |
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What is anohter name for Raloxifene?
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Evista
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what is another name for evista?
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raloxifene
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Describe mechanism of raloxifene?
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binds estrogen receptors in bone
DOESN'T bind estrogen receptors in breast |
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What are the common side effects (2) of raloxifene?
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hot flash
leg cramp |
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what drug has these 2 side fx
hot flash leg cramp |
raloxifene (evista)
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what are the 3 uses/benefits of raloxifene (evista)?
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prevent osteoporosis/CVD
prevent breast cancer prevent vaginal bleeding |
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prevent osteoporosis/CVD
prevent breast cancer prevent vaginal bleeding what drug is this? |
raloxifene (evista
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prevent osteoporosis/CVD
prevent breast cancer prevent vaginal bleeding causes leg cramp causes hot flashes what drug is this? |
raloxifene (evista
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causes leg cramp
causes hot flashes what drug is this? |
raloxifene (evista
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What form of progesterone treats abnormal uterine bleeding?
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Medroxyprogesterone (Provera)
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What is the use of medroxyprogesterone?
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tx abnormal uterine bleeding
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What are the 2 effects of testosterone?
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anabolic - increase muscle mass
androgenic - development of male 2ndary sex characteristics |
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Increases muscle mass
development of male 2ndary sex characteristics what drug is this? |
testosterone
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What are 4 side effects of testosterone
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depression
impotence na retention jaundice |
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depression
impotence na retention jaundice side effects of what? |
testosterone
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what hormone is a PED?
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testosterone
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how do they explain testosterone being an anabolic effect?
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increases formation of striated cells?
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