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39 Cards in this Set
- Front
- Back
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how to tx HIV:
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2 NRTIs
plus 1 (NNRTI, PI, CCR5, Fusion inhibitor, INSTI) only use CCR5 and FIs if no other options |
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Integrase inhibitor
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INSTI
Most use glucoronidation so no hepatic or renal issues. well tolerated |
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Protease
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Cleaves longer proteins into smaller ones which makes the virus infectious
Protease = proteins |
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RT:
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starts revers transcription of the viral RNA
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NRTI: AEs and elimination
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mitochondrial toxicity from off target DNA inhibition.
renally eliminated |
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NNRTI: metabolized and 1/2 life drug
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CYP350
ALL INDUCE CYP3A4. Efavirenz long ½ life. |
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PI combo drugs:
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if on a PI need a booster as well
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PI boosters 2:
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Ritonavir: GI AEs. inhibit CYP3A4.
Cobicistat: renal AEs. inhibit CYP3A4. cobi the dog. they got the dog when they got the kid. kidneys AEs. |
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when giving a booster, do not give what drug?
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Rifampin: bc it induces CYP3A4 and is stronger than the boosters = resistance bc low HIV drug doses
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what HIV drug do you not give with an acid suppressant?
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Atazanavir = tarzan
Tarzan cant be given acid suppressants on his diet. He might have HIV and need his meds. |
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PI AEs:
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Dyslipidemia, increased glucose, GI disturbances
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how to tx HSV and VZV?
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acyclovir
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what is the enzyme that causes activation of the prodrugs
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Thymidine kinase.
enzyme that causes the enzyme. it is the enzyme produced by the herpes virus that activates the drug inside the cell by getting a phosphate which activated the drug. |
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how does resistance against prodrugs occur?
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mutation of thymidine kinase so there is no activation of the prodrug to its active form
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what drug blocks renal secretion of acyclovir
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probenecid
prob en acyclovir |
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Tx of CMC:
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Ganciclovir: prodrug
Cidofovir: not a prodrug, so can tx acyclovir resistance. probenecid blocks renal excretion. Foscarnet:not a prodrug, so can tx acyclovir resistance GCF. causes anemia and low plts |
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how to tx influenza: 2:
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Tamiflu: PO & a prodrug.
Zanamivir: IH Zana mi, sounds like me running. zana miiii (wheezing), zana miiiii. dont give with COPD or asthma |
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what isnt helpful in tx influenza:
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The TADAs.
AmanTADAne and rimanTADAne ta da.. ended up being a trick. not useful |
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what does probenacid block (2)?
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acyclovir
cidofovir |
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how to treat HSV before sore is there?
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Abreva:
abbreviate the corse of HSV |
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When treating HSV, how many days do you have to tx?
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> 4 days
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what drug is cidal against yeast and static against mold?
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echinocandins
echo = both here and there. both kill yeast and stop mold. kill ye kill ye (hear ye hear ye) give for fungus foot |
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what drug kills both yeast and mold?
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Amphotericin B
can cause renal failure: check serum creatinine and electrolytes |
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Ivermectin
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paralyzes worm by hyperpolarization
Ever met in lightening? hyperpolarization I vermin : I = lightening. |
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Albendazole/mebendazole
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Bend: bend the tubes. inhibit the tubes from working bc they get stuck on the bank of the river.
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how to tx PCP pnm
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Pentamidine
Atovaquone you get a Pent house at Inova hospital. |
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How to tx malaria
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Atovaquone: A tova. its ova. Malaria.
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how to tx giardia
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Nitazoxanide: Nit a sox to barf/diarrhea in the woods.
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What HIV drug is the only one to target humans?
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CCR5
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What HIV drug increases warfarin?
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NNRTI: no, not warfarin!
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Fluconazole: covers
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yeast not mold
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Voriconazole covers
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yeast and molds
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how to tx serious fungal infections
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IV echinocandins
PO lamisil lam is still once the fungus is gone. |
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what drug can you not give with plavix?
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Fluconazole
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trimethoprim tx
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UTI when sulfa allergy.
tri me! when sulfa allergy! |
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Misoprosol for GI
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CI in pregnancy
mis pregancy misoprosol |
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how to treat CAP in the hospital
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ceftriaxone & azithromycin
or Moxifloxacin |
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how to tx outpt CAP
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azithromycin
Easy az |
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how to tx MDR TB
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Sirturo
we have a situation with TB |
