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16 Cards in this Set
- Front
- Back
The classic antihistamines block which receptor selectively?
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H1
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What antibody is bound to mast cells? What type of allergic reaction is this kind of histamine release?
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IgE; type 1
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T or f: histamine increases heart rate but decreases blood pressure thru vasodilation.
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T
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Explain the wheal and flare response to histamine (3 physical changes and what causes them)
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1. Reddening of the area: vascular smooth muscle dilation
2. Edematous wheal: endothelium 3. Red irregular flare surrounding wheal: axon reflex |
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What's a physiologic antagonist to histamne?
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Epinephrine
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The first generation H1 antagonists are more/less sedating and have more/less autonomic receptor blockade than 2nd generation.
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More; more
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Dramamine, benadryl, marezine, bonine, dimetane, chlor-trimenton: what are these?
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1st generation H1 antagonists
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T or f: the 1st and 2nd generation H1 antagonists are all topical.
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F! All oral
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Alleges, clairitn, clarinex, zyrtec, xyzal: what are these?
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2nd generation H1 antagonists
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Olopatadine, azelastine, bepotastine, levocabastine: what are these?
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Topical H1 antagonists
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T or f: all of the topical H1 antagonists can be used in the eye.
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T
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T or f: second generation h1 antag last longer than first
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T
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T or f: the H1 blockers work well for allergic rhinitis, urticaria, bronchial asthma and angioedema (all caused by histamine release)
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F! Only first two
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T or f: antihistamines can be found in cold and cough medicine, motion sickness medicine and OTC sleep aids.
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T
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T or f: histamine blockers have anti-adrenergic effects including urination and diarrhea
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F!!! Anti-muscarinic: dry mouth, blurred vision, urinary retention, constipation
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T or f: palpitations, nausea, headache and sedation are adverse effects of histamine blockers
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T
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