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17 Cards in this Set
- Front
- Back
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What does INH stand for?
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Isonicotinic acid Hydrazine
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What is the MOA of INH?
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Inhibits mycolic acid synthesis most effectively in dividing cells.
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How is INH metabolized?
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Hepatically
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What are some of the Side Effects of INH?
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Peripheral neuropathy, and HEPATITIS
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In what clinical circumstances is INH indicated in patients of all ages with a (+) PPD?
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HIV, Close contact with TB, skin conversion in 2 years, (+) CXR
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In what clinical circumstances is INH indicated in patients under 35 with a (+) PPD?
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Pts in countries with lots of TB, Poverty, pts residing in poor facilities, children <4 YO
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What is the MOA of Rifampin?
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Inhibits protein synthesis by blocking mRNA transcription and synthesis
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How is Rifampin metabolized?
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Hepatically
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What are some Side effects of Rifampin?
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Orange urine, saliva, sputum, tears and sweat, increased hepatic metabolism of many drugs
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Of those that we have studied in this unit, which drug is most closely related to INH?
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Pyrazinamide
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What is the MOA of Pyrazinamide?
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Unknown
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How is Pyranzinamide metabolized?
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Hepatically
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What are some side effects of Pyrazinamide?
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N&V, Hepatotoxicity, hyperuricemia and gout.
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What is the MOA of Ethambutol?
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Inihibits lipid and cell wall metabolism
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What are some side effects of Ethambutol?
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Rarely GI upset, malaise, headache, arthralgia
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What is the indicated drug regimen for pulmonary TB Tx over 6 months?
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3 drug Rx:
INH, Rifampin, pyrazinamide |
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What is the indicated drug regimen for pulmonary TB Tx over 9 months?
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Must contain both INH and rifampin
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