Pharm - Sympathomimetics

Front 1

Receptor specificity for phenylephrine, methoxamine, midodrine, pseudoephedrine and xylometazoline?

Back 1

a1>a2>>>>>>B (A pen)

Front 2

Receptor specificity for terbutaline, albuterol, L-albuterol, pirbuterol, salmeterol, formoterol and ritodine?

Back 2

b2>>b1>>>>>a

Front 3

Receptor specificity for clondine, a-methyl-dopa, dexmedetomidine, aproclonidine, brimonidine and tizanidine?

Back 3

a2>a1>>>>>>B

Front 4

MOA for phenylephrine?

Back 4

alpha agonist, vasoconstriction of veins and arteries

Front 5

Kinetics for phenylephrine?

Back 5

longer duration, not catechol = COMT degredation

Front 6

Clinical use for Phenylephrine?

Back 6

shock (IV, IM), hypotension, Decongestant (nasal spray), fundus examination of eye

Front 7

Toxicity for Phenylephrine?

Back 7

hypertension (systemic)

Front 8

MOA for methoxamine?

Back 8

alpha agonist, vasoconstriction of veins and arteries

Front 9

Kinetics for methoxamine?

Back 9

longer duration, not catechol = COMT degredation

Front 10

Clinical use methoxamine?

Back 10

hypotension

Front 11

Toxicity for methoxamine?

Back 11

hypertension (systemic)

Front 12

MOA for midodrine?

Back 12

alpha agonist, vasoconstriction of veins and arteries

Front 13

Kinetics for midodrine?

Back 13

longer duration, not catechol = no COMT degradation

Front 14

Clinical use for midodrine?

Back 14

orthostatic hypotension

Front 15

Toxicity for midodrine

Back 15

hypertension (systemic)

Front 16

MOA for pseudoephedrine?

Back 16

alters synaptic release of NE which in turn activates alpha receptors produces vasoconstriction

Front 17

Kinetics for pseudoephedrine?

Back 17

longer duration, not catechol = COMT degredation

Front 18

Clinical use for pseudoephedrine

Back 18

Nasal decogestant

Front 19

Toxicity for pseudoephedrine?

Back 19

hypertension (systemic)

Front 20

MOA for xylometazoline?

Back 20

alters synaptic release of NE which in turn activates alpha receptors produces vasoconstriction

Front 21

Kinetics for xylometazoline?

Back 21

longer duration, not catechol = no COMT degradation

Front 22

Clinical use for xylometazoline?

Back 22

nasal decongestant

Front 23

Toxicity for xylometazoline?

Back 23

hypertension (systemic)

Front 24

MOA for oxymetazoline?

Back 24

alters synaptic release of NE which in turn activates alpha receptors produces vasoconstriction + some a2 activity

Front 25

Kinetics for oxymetazoline?

Back 25

longer duration, not catechol = no COMT degradation

Front 26

Clinical use for oxymetazoline?

Back 26

nasal decongestant

Front 27

Toxicity for oxymetazoline?

Back 27

may cause hypotension

Front 28

MOA for terbutaline, albuterol, L-albuterol, pirbuterol, salmeterol, formoterol and ritodrine?

Back 28

b2 selective agonist, bronchodilation, these drugs will be the focus of the Asthma lecture

Front 29

MOA for theophyline?

Back 29

phosphodiesterase inhibitor, adenosine antagonist

Front 30

MOA for clondine, a-methyl-dopa, dexmedetomidine, aproclonidine, brimonidine and tizanidine?

Back 30

presynaptic inhibition of synaptic vesicle release. In sympathetic neuorns decreases sympathetic output from CNS

Front 31

Kinetics for terbutaline, albuterol, L-albuterol and pirbuterol?

Back 31

short duration, bulky side groups prevent breakdown by COMT, poor oral bioavailability

Front 32

Clinical use for terbutaline, albuterol, L-albuterol and pirbuterol?

Back 32

asthma (as needed)

Front 33

Toxicity for terbutaline, albuterol, L-albuterol and pirbuterol?

Back 33

skeletal muscle tremor, tachycardia, reduced oxygen tension, downregulation of receptors (immune cells less on lungs except in genetic variants)

Front 34

Kinetics for Salmeterol and formoterol?

Back 34

long duration

Front 35

Clinical use of Salmeterol and formoterol?

Back 35

asthma (moderate to severe)

Front 36

Toxicity of Salmeterol and formoterol?

Back 36

skeletal muscle tremor, tachycardia, reduced oxygen tension, downregulation of receptors (immune cells less on lungs except in genetic variants)

Front 37

Kinetics for Ritodrine?

Back 37

long duration + IV

Front 38

Clinical use of Ritodrine?

Back 38

uterine relaxation

Front 39

Toxicity of Ritodrine?

Back 39

skeletal muscle tremor, tachycardia, reduced oxygen tension, downregulation of receptors (immune cells less on lungs except in genetic variants)

Front 40

Kinetics of Theophylline?

Back 40

PO

Front 41

Clinical use of Theophylline?

Back 41

Asthma

Front 42

Toxicity of Theophylline?

Back 42

increased heart rate, nervousness and tremors

Front 43

Clinical use of Clondine, a-methyl-dopa, dexmedetomidine, aproclonidine and brimonidine?

Back 43

Hypertension (and others)

Front 44

Toxicity of Clondine, a-methyl-dopa, dexmedetomidine, aproclonidine and brimonidine?

Back 44

sedation, dry mouth, constipation and impotence