Pharm Suffixes 4

Front 1

-cillin

Back 1

Penicillins (class of Beta Lactams)
Inhibit transpeptidation, cell wall synthesis.

Hint 1

=Natural
Peni- (G,V)
=Penicillinase resistent
Methi-
Cloxa-
=extended range
Ampi-
Amoxi-
=psudomonal
Carbeni-
Ticar-
Piper-

Front 2

Cef-

Back 2

Cephalosporins (class of Beta Lactams)
Inhibit transpeptidation, cell wall synthesis.

Hint 2

1st Gen
-azolin
2nd
-otetan
-otoxitin
-uroxime
also Loracarbef
3rd
-triazone
-trazidime
-operazone
4th
-epime

Front 3

-penem

Back 3

Carbapenems (class of Beta Lactams)
Inhibit transpeptidation, cell wall synthesis.

Hint 3

Imi-
Mero-
Erta-

Front 4

-cycline

Back 4

Tetracyclines/Glycylcylcine
Bind 30S and inhibit bacterial protein synthesis

Hint 4

=Tetra
Tetra-
Doxy-
=Glycyl
Tige-

Front 5

-THROmycin

Back 5

Macrolides/Ketolides.
Bind 50S and inhibit bacterial protein synthesis.

Hint 5

=Macrolides
Ery-
Clari-
Azi-
=Ketolide
Teli-

Front 6

-oxazole

Back 6

Sulfonamides.
Inhibit dihydropteroate synthase. (Trimethoprim inhibits dhpt reductase)
Prevent folate synthese, ergo nucleic acid synthesis

Hint 6

Sulfis-
Sulfameth-

Front 7

-floxacin

Back 7

Fluoroquinolones.
Inhibit DNA gyrase.
Bc G-

Hint 7

Cipro-
Lexo-

Front 8

Rifa-

Back 8

Rifamycins.
Inhibit RNA synthesis.

Front 9

-mantadine

Back 9

Inhibits viral uncoating via M2 protein.
Treats Influenza A

Hint 9

A-
Ri-

Front 10

-amivir

Back 10

Block viral budding.
Inhibits viral neuraminidase, prevents cleavage of sialic acid.
Treats Influenza A & B.

Hint 10

Zan-
Oselt-

Front 11

-ciclovir
-cyclovir

Back 11

Guanosine (guanine nucleoside) analog.
Acyclovirs and analogs treat Hepres simplex 1& 2 and varicella zoster.
Ganciclovir is used for CMV.

Hint 11

Acy-
Valacy-
Penci-
Famci-

Ganci-

Front 12

-cavir

Back 12

Guanosine analog nucleoSide reverse transcriptase inhibitors.
Abacavir = HIV
Entecavir = HBV

Hint 12

Aba-
Ente-

Front 13

-fovir

Back 13

NucleoTide reverse transcriptase inhibitors.
Tenofovir = HIV
Cidofovir = CMV
Adefovir = HBV

Hint 13

Teno-
Cido-
Ade-

Front 14

-navir

Back 14

HIV protease inhibitors.
Block cleavage of gag-pol precursor.

Hint 14

Amprenavir/Fosamprenavir
Atazanavir
Darunavir
Indinavir
Lopinavir
Nelfinavir
Ritonavir
Saquinavir
Tipranavir

Front 15

-conazole

Back 15

Azoles (antifungal).
Inhibit 14-alpha-demethylase (a P-450).
Prevent ergosterol synthesis

Hint 15

Flu-
Intra-
Keto-
Poso-
Vori-

Front 16

-afine

Back 16

Allylamines.
Inhibit fungal squalene oxidase.

Hint 16

Naft-
Terbin-
Buten-

Front 17

-fungin

Back 17

Echinocandins.
Inhibit glucan synthase. Glucan in used in fungal cell wall.

Hint 17

Caspo-
Mica-

Front 18

-mustine

Back 18

Chloroethyl nitrosoureas.
Heterobifunctional alkylating agents for cancer chemo.
Also can cause DNA crosslinking and carbamoylation of proteins.
CNS available.

Hint 18

Car-
Lo-

Front 19

-platin

Back 19

Platinum coorditing alkylating agents for cancer chemo.
Testicular, ocarian, heand and neck cancers.

Hint 19

Cis-
Oxali-
Carbo-

Front 20

Vin-

Back 20

Vinca Alkaloids (from plants).
Bind to tubulin, favor depolymerization.
Tox: Granulocytopenia.

Hint 20

-cristine
-blastine
-orelbine

Front 21

-taxel

Back 21

Taxanes: diterpene antineoplastics from western yew tree.
Bind to tubulin, make it super stable (inhibit dynamic processes like mitosis).
Tox: neutropenia, mucositis.

Hint 21

Pacli-
Doce-

Front 22

-poside

Back 22

Epipodophyllotoxins from mandrake plant.
Inhibit topoisomerase II.
Treat Hodgkin's, diffuse histiocytic lymphoma and SCC of lung.
Tox: leukopenia, thrombocytopenia

Hint 22

Eto-
Teni-

Front 23

-tecan

Back 23

Camptothecins.
Inhibit topoisomerase I.
Irino: metastatic colon cancer
Topo: ovarian and SCC of lung

Hint 23

Irino-
Topo-

Front 24

-rubicin

Back 24

Antrhacycline antibiotics used in cancer chemotherapy.
Mech: DNA intercalation/single stranded breaks.

Hint 24

Dauno-
Doxo-

Front 25

-tinib

Back 25

Tyrosine kinase inhibitors
Ima: Blocks c-abl kinase (translocated to bcr region of ch22).
Treats CML and Ph+ ALL

Erlo, Gefi: inhibits EGF receptor.
Treats non-SCC of lung and pancreatic cancer

Hint 25

Ima-
Erlo-
Gefi-

Front 26

-mab (chemo)

Back 26

Monoclonal antibodioes
Ceruxi: EGF receptor - head, neck, metastatic colon cancer
Trastuzu: p185-her2 positive breast cancer.
Bevacizu: VEGF receptor - inhibits angiogenesis in lung, colon cancer.
Rituxi: anti-CD20 - non-Hodgkins B cell lymphoma
Gemtuzu: anti CD33

Hint 26

Ceruxi-
Trastuzu-
Bevacizu-
Rituxi-
Gemtuzu-

Front 27

-trozole

Back 27

Selective & reversible aromatase inhibitors.
Treat breast cancer.
Used for only postmenopausal women.

Hint 27

Anas-
Le-
also Exemestane

Front 28

-quine

Back 28

Malarials

Hint 28

Meflo-
Chloro-
Also Quinine and Quindidine

Front 29

-bendazole

Back 29

Benzimadozoles.
Bind beta-tubulin, inhibit microtubule polymerization.
Anti-Nematodes: T. trichiura, Ascaris, Capillariasis, Necator americanus

Hint 29

Al-
Me-
Thia-