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42 Cards in this Set
- Front
- Back
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Cell Wall Synthesis Inhibitors
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Vancomycin
Bacitracin Penicillins Cephalosporins Cycloserine Fosfomycin |
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Folic acid metabolism
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Trimethoprim (Blocks DHFA to THFA)
Sulfonamides (Blocks conversion to DHFA) |
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Modify Nucleic Acid /DNA Synthesis
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Nalidixic acid
Quinilones Rifampin |
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Protein Synthesis Inhibitors (50S)
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Erythromycin
Cloramphenicol Clindamycin Oxazolidinone Quinupristin Dalfopristin |
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Protein Synthesis Inhibitors (30s)
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Tetracycline
Spectinomycin Streptomycin Gentamycin, Tobramycin Amikacin |
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Cell membrane
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Polymyxins
Aminoglycosides Lipopeptides |
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Adverse Effects
Renal toxicity |
Cephalosporins
Vancomycin Aminoglycosides Sulfonamides Amphotericin B Cisplatin |
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Adverse Effects
Hepatotoxicity |
Tetracylines
Erythromycin estolate Clindamycin methotrexate 6-mercaptopurine Sulfonamides Amphotericin B Daunorubicin Doxorubicin |
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Adverse Effects
Ototoxicity |
Aminoglycosides
Vancomycin Minocycline (Vestibular only) |
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Adverse Effects
Visual Toxicity |
Ethambutol
Isoniazid |
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Adverse Effects
Hemopoietic Toxicity |
Most antineoplastic Compounds
Many antiviral Genes Chloramphenicol Sulfonamides |
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Adverse Effects
Allergies |
Anaphylactic shock
Skin Rashes Immune induced blood dyscrasias Immune hemolytic anemias |
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Adverse Effects
Hemolytic anemias |
Sulfonamides
Nitrofurantoin |
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Adverse Effects
Photosensitivity |
Tetracyclines
floroquinolones |
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Mechanism of Action
Macrolides |
50s, inhibit translocation
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Mechanism of Action
Chloramphenicol |
50s, inhibit transpeptidation
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Mechanism of Action
Aminoglycosides |
30s, Blocks initiation elicits premature termination incorportation.
Incorrect Aminoacid |
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Mechanism of Action
Tetracycline |
30s, prevent binding the incoming charged tRNA
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Mechanism of Action
Fluroquinolones |
Inhibiting topoisomerase
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Mechanism of Action
Rifampin |
Inhibits DNA dependent RNA polymerase
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Mechanism of Action
Sulfonamides |
Inhibition of folic acid synthesis
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Mechanism of Action
Beta Lactams |
inhibition of cell wall synthesis
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Mechanism of Action
Vancomycin |
Inhibition of peptidoglycan chin elongation
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Mechanism of Resistance
Macrolides |
methyltransferases alter the binding site
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Mechanism of Resistance
Chloramphenicol |
Inactivating acetyltransferases
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Mechanism of Resistance
Aminoglycosides |
Acetyl, phosphoryl or adenylyl conjugation
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Mechanism of Resistance
Tetracyclines |
Pump out
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Mechanism of Resistance
Fluroquinolones |
Change in sensitivity of TE
Pump out |
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Mechanism of Resistance
Rifampin |
Change in Enzyme
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Mechanism of Resistance
Sulfonamides |
Decrease sensitivity of the target enzymes,
Increased formation of PABA, Use of exogenous folate |
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Mechanism of Resistance
Beta lactams |
penicillinase
Modification of PBP-s Change of Porins |
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Mechanism of Resistance
Vancomycin |
Change in penta peptide
D-ala-D-Lactate |
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Prophylactic agents
Genital Herpes Simplex |
acyclovir
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Prophylactic agents
Group B Strep |
Ampicillin
Penicillin G |
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Prophylactic agents
Haemophilus influenzae Type B |
Rifampin
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Prophylactic agents
Malaria |
Chloroquine
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Prophylactic agents
Meningococcal |
Rifampin
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Prophylactic agents
Pertussis |
erythromycin
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Prophylactic agents
Pneumocystis Carinii |
TMP-SMX
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Prophylactic agents
Tuberculosis |
Isoniazid
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Prophylactic agents
UTI |
TMP-SMX
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Prophylactic agents
Anthrax |
Ciprofloxin
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