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22 Cards in this Set
- Front
- Back
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What is adaptive anxiety?
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-Appropriate rxn to danger
-Fear, arousal -Increased sympathetic activity |
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What is maladaptive anxiety?
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-Chronic, psychological stress
-Organ dysfunction, physical s/sx -GI, cardiac, substance abx |
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Location of anxiety?
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Amygdala
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DOC for acute anxiety?
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Bzd
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DOC for panic disorder?
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SSRIs
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DOC for phobias?
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SSRIs
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DOC for OCD?
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SSRIs
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DOC for GAD?
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Bzd, buspirone
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DOC for PTSD?
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Antidepressants
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DOC for enuresis?
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TCAs
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How many stages of sleep?
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1-4 plus REM
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What are the effects of sleep-drugs on sleep?
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Suppression of stage 3, slow wave, and REM
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How many GABA receptors are there?
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3
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Which type of GABA receptor do barbs, bzds, and ETOH work at?
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GABAa
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BZD MOA?
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-Work at site next to GABA receptors
-Works only when GABA is present in channel -At high doses, decreases GABA release for ceiling effect |
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BZD pharmacokinetics
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-Lipid soluble
-Readily enters brain |
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BZDs for insomnia
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-Flurazepam (Dalmane)
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Barbs MOA
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-Increases affinity of GABA to its receptor, increasing the time the Cl- channel is open
-Opens the Cl- independently of GABA -Linear dose response with no ceiling |
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Antihistamine MOA
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-Block H1 receptor
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Zolpidem (Ambien) & Zalepon (Sonata) MOA
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-Blocks BZD receptor subtype BZ1
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Eszopiclone (Lunesta) MOA
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-Similar to Ambien but blocks all BZ receptors
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Ramelteon (Rozerem)
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-Melatonin analogue
-Promotes sleepiness w/o GABA effect -No effect on REM |
