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40 Cards in this Set

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3 MAOIs
Phenelzine
Tranylcypromine
Isocarboxazid
Trazodone
Heteocyclic 2nd generation AD
Blocks 5-HT reuptake.
Venlafaxine
Heterocyclic AD that inhibits 5-HT, NE and DA reuptake.
Mirtazapine
Alpha-2 antagonist and 5-HT antagonist. Causes sedatio and wt gain.
Maprotiline
Heterocyclic AD that blocks NE uptake.
Formula for clearance
Cl=Ke * Vd
or
half-life = .7 *Vd/CL
Infusion rate (constant)
Infusion rate =
CL * Conc desired
Dose(intermittent)to achieve desired conc
Dose = Conc desired*CL *dosing interval
Ke
Ke = .7/half-life
Side effect of interferons.
pancytopenia.
Formula for clearance
Clearance = Rate of elim/Conc.
What agent to use with diabetes that doesn't cause hypoglycemia?
Glitazones (Pilglitazone, Rosiglitazone). Increase insulin sensitivity).
2 diabetic agents that cause disulfiram-like effects:
1st generation sulfonylureas:
1. Tolbutamide
2. Chlorpropamide
Formula for maintenance dose
= Conc *Cl/f
Treatment for typical pneumonia.
Ceftriazone. Causal agents: Strep pneumo, staph aureus, h flu.
What is clindamycin used for?
anaerobes above the diaphragm (clostridium,bacteroides fragilis)
Treatment for atypical pneumoia
macrolides (erythyromycin, azithromycin, clarithromycin)
Tx for breast cancer (HER-2).
Trastuzumab
Treatment for chronic myoloid leukemia that inhibits brc-abl Philly chromostome
Imatinib
5 effects on serum levels of pts using thiazide diuretics
1. Increase glucose
2. Increase lipids
3. Inceased uricemia
4. Increased calcium
5. Hyponatremia
p450 inhibitors
Chloramphenical
Cimetidine
clarithromycin
disulfiram
erythromycin
grapefruit juice
fluconozole
isoniazid
MAO inhibitors
phenylbutazone
secobarbital
-azoles affect on p450?
inhibit
p450
Quinidine
inducer
p450
barbiturates
inducer
p450
Phenytoin
inducer
p450
Rifampin
inducer
p450
Rifampin
inducer
p450
Griseofulvin
inducer
p450
carbamazpine
inducer
p450
St John's Wart
inducer
p450
Isonizaid
inhibitor
p450
Cimetidine
inhibitor
p450
Sulfonamides
inhibitor
p450
Ketoconzole
inhibitor
p450
erythromycin
inhibitor
p450
griseofulvin
inducer
prophylactic tx for pneumo carinii in HIV+
trimeth-sulfameth
Start when CD4<200
p450
griseofulvin
inducer
how to tx pseudomonas infection in pt c penicillin allergy
aztreonam, a monobactam .
tricyclic antidepressant used to tx bedwetting.
How to tx overdose
Imipramime.
Sodium bicarb.