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40 Cards in this Set
- Front
- Back
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3 MAOIs
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Phenelzine
Tranylcypromine Isocarboxazid |
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Trazodone
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Heteocyclic 2nd generation AD
Blocks 5-HT reuptake. |
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Venlafaxine
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Heterocyclic AD that inhibits 5-HT, NE and DA reuptake.
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Mirtazapine
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Alpha-2 antagonist and 5-HT antagonist. Causes sedatio and wt gain.
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Maprotiline
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Heterocyclic AD that blocks NE uptake.
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Formula for clearance
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Cl=Ke * Vd
or half-life = .7 *Vd/CL |
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Infusion rate (constant)
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Infusion rate =
CL * Conc desired |
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Dose(intermittent)to achieve desired conc
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Dose = Conc desired*CL *dosing interval
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Ke
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Ke = .7/half-life
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Side effect of interferons.
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pancytopenia.
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Formula for clearance
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Clearance = Rate of elim/Conc.
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What agent to use with diabetes that doesn't cause hypoglycemia?
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Glitazones (Pilglitazone, Rosiglitazone). Increase insulin sensitivity).
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2 diabetic agents that cause disulfiram-like effects:
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1st generation sulfonylureas:
1. Tolbutamide 2. Chlorpropamide |
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Formula for maintenance dose
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= Conc *Cl/f
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Treatment for typical pneumonia.
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Ceftriazone. Causal agents: Strep pneumo, staph aureus, h flu.
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What is clindamycin used for?
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anaerobes above the diaphragm (clostridium,bacteroides fragilis)
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Treatment for atypical pneumoia
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macrolides (erythyromycin, azithromycin, clarithromycin)
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Tx for breast cancer (HER-2).
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Trastuzumab
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Treatment for chronic myoloid leukemia that inhibits brc-abl Philly chromostome
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Imatinib
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5 effects on serum levels of pts using thiazide diuretics
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1. Increase glucose
2. Increase lipids 3. Inceased uricemia 4. Increased calcium 5. Hyponatremia |
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p450 inhibitors
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Chloramphenical
Cimetidine clarithromycin disulfiram erythromycin grapefruit juice fluconozole isoniazid MAO inhibitors phenylbutazone secobarbital |
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-azoles affect on p450?
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inhibit
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p450
Quinidine |
inducer
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p450
barbiturates |
inducer
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p450
Phenytoin |
inducer
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p450
Rifampin |
inducer
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p450
Rifampin |
inducer
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p450
Griseofulvin |
inducer
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p450
carbamazpine |
inducer
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p450
St John's Wart |
inducer
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p450
Isonizaid |
inhibitor
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p450
Cimetidine |
inhibitor
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p450
Sulfonamides |
inhibitor
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p450
Ketoconzole |
inhibitor
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p450
erythromycin |
inhibitor
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p450
griseofulvin |
inducer
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prophylactic tx for pneumo carinii in HIV+
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trimeth-sulfameth
Start when CD4<200 |
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p450
griseofulvin |
inducer
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how to tx pseudomonas infection in pt c penicillin allergy
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aztreonam, a monobactam .
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tricyclic antidepressant used to tx bedwetting.
How to tx overdose |
Imipramime.
Sodium bicarb. |
