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26 Cards in this Set
- Front
- Back
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PDP, ACE Inhibitors
Captopril Characteristics |
only one with sulfhydryl group and shortest duration
orally effects half life 2 hrs food reduces bioavailability |
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PDP, ACE Inhibitors
Captopril Use |
hypertension, mild - low does have limited Side E;
diabetic neuropathy no reflex tachycardia HF, post MI, angina |
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PDP, ACE Inhibitors
Captopril Side E |
hyperkalemia
DO NOT use with triamterene or amiloride proteinuria, neutropenia taste loss, rash all reversible COUGH inc renin and ATI |
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PDP, ACE Inhibitors
Captopril Drug Interactions |
with diuretics - prevent hypokalemia
with insulin - hypoglycemia |
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PDP, ACE Inhibitors
Enalapril structure |
carboxyl group, no sulfhydryl (which makes Side E)
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PDP, ACE Inhibitors
Enalapril characteristics |
prodrug
bioavail not affected by food, 50% bound in plasma, half life 11 hrs IV |
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PDP, ACE Inhibitors
Enalapril Use |
once a day
if hypersenitive to catropril |
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PDP, ACE Inhibitors
Lisinopril characterisitcs |
oral, 12 hr half life
no plasma binding once per day |
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PDP, ACE Inhibitors
Benazepril |
most potent
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AT II Antag
Losartan potassium Mech |
imidazole derivative
block binding of ATII to AT-1 receptor |
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AT II Antag
Losartan potassium Characteristics |
absorbed rapidly
effective 1 hr half life 1.5-2.5 hrs metabolite has longer half life |
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AT II Antag
Valsartan Characteristic |
similar to losartan
food dec absorption |
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Renin Inhib
Aliskiren chara |
blocks renin
oral; poor bioavailibility long half life |
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Renin Inhib
Aliskiren Side E |
diarrhea
hyperkalemia |
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ADH
Secretion Inc by |
elevated serum osmolality
dec extracellular vol angiotensin II clofibrate |
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ADH
Receptors |
V1a - SM, vascular and brain
V1b pituitary V2 apical surface of collecting duct |
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ADH
Effects Renal |
vasoconstrictor
V2 H2O perm. V1a Dec. inner medullary blood flow |
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ADH
Effects extra-Renal |
Inc water/salt intake
inc factor VIII syn inc ACTH release |
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Desmopressin
features |
Long duration, 14-20 h
intranasal/oral/IV V2 receptors |
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Tannin Vasopressin
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short acting
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Lysine vasopressin
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more stable
IV/intranasal |
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ADH Agonists
Uses |
Central Diabetes insipidus (not nephrogenic)
Gi bleeding esophageal variceal bleeding NOT in GI Ulcers |
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Drugs of choice in nephrogenic DI
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thiazide diuretics
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ADH Antag. Drugs
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Demecloclycline
Lithium |
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ADH Antag. Drugs
Demecloclycline Mech |
interferes with water perm. of collecting duct
NO cAMP changes |
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ADH Antag. Drugs
Lithium Mech |
antag ADH by inc cAMP
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