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17 Cards in this Set
- Front
- Back
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Strength of interaction between drug and its receptor
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Affinity
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Selectivity of a drug for its receptor
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Specificity
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Amount of drug necessary to elicit a biologic effect
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Potency
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Ability of drug to produce a biologic effect
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Efficacy
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Ability of a drug to produce 100% of the maximum response regardless of the potency
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Full agonist
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Ability to produce less than 100% of the response
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Partial agonist
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Ability to bind reversibly to the same site as the drug and without activating the effector system
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Competitive antagonist
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Ability to bind to either the same or different site as the drug
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Noncompetitive antagonist
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Mechanism of action (MOA) utilizes intracellular receptors
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Thyroid and steroid hormones
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MOA utilizes transmembrane receptors
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Insulin
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MOA utilizes ligand gated ion channels
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Benzodiazepines and calcium channel blockers
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Median effective dose required for an effect in 50% of the population
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ED50
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Median toxic dose required for a toxic effect in 50% of the population
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TD50
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Dose which is lethal to 50% of the population
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LD50
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Window between therapeutic effect and toxic effect
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Therapeutic index
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Drug with a high margin of safety
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High therapeutic index
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Drug with a narrow margin of safety
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Low therapeutic index
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