Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
11 Cards in this Set
- Front
- Back
|
What are the Gram (+) and Gram (-) cell walls made out of?
|
1. Peptidoglycan only
2. LPS + Peptidoglycan + others(Porins) |
|
|
How do the PCNs act?(2)
|
1. Interact with PBPs
2. Inhibit Transpeptidation |
|
|
What are the first generation PCNs?(2)
|
1. PCN V
2. PCN G(Syphillis) |
|
|
What are some Generation 2 PCNs?(3)
|
1. Methicillin
2. Naficillin 3. Oxacillin |
|
|
How is naficillin metabolized?(2)
|
1. Fat soluble so through the bile
2. Can cause seizures |
|
|
What were the Generation 2 PCNs mainly used for?
|
1. Staph
2. They were over used and this is why we have MRSA |
|
|
Name 2 Generation 3 PCNs?
|
1. Amoxicillin(B. burgdoferi, H. pylori)
2. Ampicillin(Lysteria) |
|
|
What are the Generation 3 PCNs normally combined with?(3)
|
1. Suicide inhibitors(Destroy Beta lactamases)
2. Amoxicillin with Sulbactam 3. Ampicillin with Clavulonic acid |
|
|
Name four generation 4 PCNs and their main target?
|
1. Carbenicillin
2. Azlocillin 3. Ticarcillin 4. Pipercillin 1. Pseudomonas aeruginosa |
|
|
What are the side effects of Generation 1 PCN?
|
1. Jarrisch Herxheimer happens when lots of Spirochetes Die(Chills, fever, malaise, Mayalgia)
2. Type 1 Hypersensitivity |
|
|
What are the Side Effects of generation two PCNs?
|
1. Methicillin can cause interstitial nephritis
|
