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50 Cards in this Set
- Front
- Back
Antimuscarinics that produce mydriasis and cycloplegia (3)
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Atropine, homatropine, tropicamide
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Anticholinergic causing bronchodilation in asthma and COPD
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Ipratropium
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Reduce transient hyper GI motility
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Dicyclomine, methscopolamine
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Anticholinergics used in cystitis, postoperative bladder spasms, or incontinence (2)
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Oxybutynin, dicyclomine
cystitis - cyclomine |
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Toxicity of anticholinergics
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block SLUD (salivation, lacrimation, urination, defecation
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Another mnemonic for anticholinergic toxicity
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"dry as a bone, red as a beet, mad as a hatter, hot as a hare, blind as a bat"
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Atropine fever is the most dangerous effect and can be lethal in this population group
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Infants
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Contraindications to use of atropine (3)
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Infants, closed angle glaucoma, prostatic hypertrophy
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Nicotinic Antagonists
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Limiting adverse effect of ganglion blockade that patients usually are unable to tolerate
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Severe hypertension
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These agents cause reversal of blockade by neuromuscular blockers
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Cholinesterase inhibitors
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Tubocurarine is the prototype, pancuronium, atracurium, vecuronium are newer short acting agent, produce competitive block at end plate nicotinic receptor, causing flaccid paralysis
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Nondepolarizing Neuromuscular Blockers
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Only member of depolarizing neuromuscular blocker, causes fasciculation during induction and muscle pain after use; has short duration of action
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Succinylcholine
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Chemical antagonists that bind to the inhibitor of ACh Estrace and displace the enzyme (if aging has not occurred)
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Cholinesterase regenerators, pralidoxime
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Used to treat patients exposed to insecticides such as parathion
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Pralidoxime, atropine
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Sympathomimetics
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Pneumonic for beta receptors
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You have 1 heart (Beta 1) and 2 lungs (Beta 2)
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This is the drug of choice for anaphylactic shock
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Epinephrine
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Phenylisopropylamines that are used legitimately and abused for narcolepsy, attention deficit disorder, and weight reduction
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Amphetamines
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Alpha agonist used to produce mydriasis and reduce conjunctival itching and congestion caused by irritation or allergy, it does not cause cycloplegia
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Phenylephrine
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Newer alpha 2 agonist (apraclonidine and brimonidine) treat glaucoma by acting to
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Reduce aqueous secretion
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Short acting Beta 2 agonists that is drug of choice in treatment of acute asthma but not recommended for prophylaxis
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albuterol
alBu2rol |
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Longer acting Beta 2 agonist is recommended for prophylaxis of asthma
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Salmeterol
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These agents increase cardiac output and may be beneficial in treatment of acute heart failure and some types of shock
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Beta1 agonists
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These agents decrease blood flow or increase blood pressure, are local decongestants, and used in therapy of spinal shock (temporary maintenance of blood pressure which may help maintain perfusion
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Alpha1 agonists
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Shock due to septicemia or myocardial infarction is made worse by
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Increasing afterload and tissue perfusion declines
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Epinephrine is often mixed with a local anesthetic to
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Reduce the loss from area of injection
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Chronic orthostatic hypotension can be treated with this drug
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Midodrine
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Beta 2 agonist used to suppress premature labor, but cardiac stimulatory effects may be hazardous to mother and fetus
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Terbutaline
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Sympathetic agent which stimulates heart rate and can dilate vessels in skeletal muscle at low doses
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Epinephrine
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Sympathomimetic that works on mast cells to reduce release of histamine and inflammatory mediators
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Epinephrine
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Agent used in shock because it dilates coronary arteries and increases renal blood flow
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Dopamine
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Agent which stimulates cardiac contractile force more than rate with little effect on total peripheral resistance
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Dobutamine
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Long acting sympathomimetic, sometimes used to improve urinary continence in children and elderly with enuresis
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Ephedrine
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Alpha 1 agonist toxicity
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Hypertension
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Beta 1 agonist toxicity
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Sinus tachycardia and serious arrhythmias
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Beta 2 agonist toxicity
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Skeletal muscle tremor, tachycardia
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The selective agents loose their selectivity at
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high doses
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Adrenoceptor Blocker
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Nonselective alpha-blocking drug, long acting and irreversible, and used to treat pheochromocytoma. Blocks 5-HT, so occasionaly used for carcinoid tumor. Blocks H1 and used in mastocytosis
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Phenoxybenzamine
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Nonselective alpha-blocking drug, short acting and reversible, used for rebound HTN from rapid clonidine withdrawal, and Raynaud's phenomena
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Phentolamine
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Selective Alpha 1 blockers used for hypertension, BPH, may cause first dose orthostatic hypotension (3)
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Prazosin, terazosin, doxazosin
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Selective Alpha-1A blocker, used for BPH, but with little effect on HTN
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Tamsulosin
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Selective Alpha 2 blocker used for impotence (controversial effectiveness)
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Yohimbine
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Beta-Blocking Drugs
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Selective B1 Receptor blockers that may be useful in treating patients even though they have asthma
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Acebutolol, atenolol, esmolol, metoprolol
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Combined alpha and beta blocking agents that may have application in treatment of CHF
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Labetalol and carvedilol
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Beta blockers with partial agonist activity (intrinsic sympathomimetic activity), cause some bronchodilation and may have an advantage in treating patients with asthma (2)
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Pindolol and acebutolol
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This beta blocker lacks local anesthetic activity (a property which decreases protective reflexes and increases the risk of corneal ulceration) and used in treating glaucoma
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Timolol
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This parenteral beta blocker is a short acting (minutes)
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Esmolol
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