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50 Cards in this Set

  • Front
  • Back
Antimuscarinics that produce mydriasis and cycloplegia (3)
Atropine, homatropine, tropicamide
Anticholinergic causing bronchodilation in asthma and COPD
Ipratropium
Reduce transient hyper GI motility
Dicyclomine, methscopolamine
Anticholinergics used in cystitis, postoperative bladder spasms, or incontinence (2)
Oxybutynin, dicyclomine

cystitis - cyclomine
Toxicity of anticholinergics
block SLUD (salivation, lacrimation, urination, defecation
Another mnemonic for anticholinergic toxicity
"dry as a bone, red as a beet, mad as a hatter, hot as a hare, blind as a bat"
Atropine fever is the most dangerous effect and can be lethal in this population group
Infants
Contraindications to use of atropine (3)
Infants, closed angle glaucoma, prostatic hypertrophy
Nicotinic Antagonists
Limiting adverse effect of ganglion blockade that patients usually are unable to tolerate
Severe hypertension
These agents cause reversal of blockade by neuromuscular blockers
Cholinesterase inhibitors
Tubocurarine is the prototype, pancuronium, atracurium, vecuronium are newer short acting agent, produce competitive block at end plate nicotinic receptor, causing flaccid paralysis
Nondepolarizing Neuromuscular Blockers
Only member of depolarizing neuromuscular blocker, causes fasciculation during induction and muscle pain after use; has short duration of action
Succinylcholine
Chemical antagonists that bind to the inhibitor of ACh Estrace and displace the enzyme (if aging has not occurred)
Cholinesterase regenerators, pralidoxime
Used to treat patients exposed to insecticides such as parathion
Pralidoxime, atropine
Sympathomimetics
Pneumonic for beta receptors
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
This is the drug of choice for anaphylactic shock
Epinephrine
Phenylisopropylamines that are used legitimately and abused for narcolepsy, attention deficit disorder, and weight reduction
Amphetamines
Alpha agonist used to produce mydriasis and reduce conjunctival itching and congestion caused by irritation or allergy, it does not cause cycloplegia
Phenylephrine
Newer alpha 2 agonist (apraclonidine and brimonidine) treat glaucoma by acting to
Reduce aqueous secretion
Short acting Beta 2 agonists that is drug of choice in treatment of acute asthma but not recommended for prophylaxis
albuterol

alBu2rol
Longer acting Beta 2 agonist is recommended for prophylaxis of asthma
Salmeterol
These agents increase cardiac output and may be beneficial in treatment of acute heart failure and some types of shock
Beta1 agonists
These agents decrease blood flow or increase blood pressure, are local decongestants, and used in therapy of spinal shock (temporary maintenance of blood pressure which may help maintain perfusion
Alpha1 agonists
Shock due to septicemia or myocardial infarction is made worse by
Increasing afterload and tissue perfusion declines
Epinephrine is often mixed with a local anesthetic to
Reduce the loss from area of injection
Chronic orthostatic hypotension can be treated with this drug
Midodrine
Beta 2 agonist used to suppress premature labor, but cardiac stimulatory effects may be hazardous to mother and fetus
Terbutaline
Sympathetic agent which stimulates heart rate and can dilate vessels in skeletal muscle at low doses
Epinephrine
Sympathomimetic that works on mast cells to reduce release of histamine and inflammatory mediators
Epinephrine
Agent used in shock because it dilates coronary arteries and increases renal blood flow
Dopamine
Agent which stimulates cardiac contractile force more than rate with little effect on total peripheral resistance
Dobutamine
Long acting sympathomimetic, sometimes used to improve urinary continence in children and elderly with enuresis
Ephedrine
Alpha 1 agonist toxicity
Hypertension
Beta 1 agonist toxicity
Sinus tachycardia and serious arrhythmias
Beta 2 agonist toxicity
Skeletal muscle tremor, tachycardia
The selective agents loose their selectivity at
high doses
Adrenoceptor Blocker
Nonselective alpha-blocking drug, long acting and irreversible, and used to treat pheochromocytoma. Blocks 5-HT, so occasionaly used for carcinoid tumor. Blocks H1 and used in mastocytosis
Phenoxybenzamine
Nonselective alpha-blocking drug, short acting and reversible, used for rebound HTN from rapid clonidine withdrawal, and Raynaud's phenomena
Phentolamine
Selective Alpha 1 blockers used for hypertension, BPH, may cause first dose orthostatic hypotension (3)
Prazosin, terazosin, doxazosin
Selective Alpha-1A blocker, used for BPH, but with little effect on HTN
Tamsulosin
Selective Alpha 2 blocker used for impotence (controversial effectiveness)
Yohimbine
Beta-Blocking Drugs
Selective B1 Receptor blockers that may be useful in treating patients even though they have asthma
Acebutolol, atenolol, esmolol, metoprolol
Combined alpha and beta blocking agents that may have application in treatment of CHF
Labetalol and carvedilol
Beta blockers with partial agonist activity (intrinsic sympathomimetic activity), cause some bronchodilation and may have an advantage in treating patients with asthma (2)
Pindolol and acebutolol
This beta blocker lacks local anesthetic activity (a property which decreases protective reflexes and increases the risk of corneal ulceration) and used in treating glaucoma
Timolol
This parenteral beta blocker is a short acting (minutes)
Esmolol