Pharm Oneliners Sets Of 50 Part 2

Front 1

Antidote used for benzodiazepine toxicity

Back 1

Flumazenil

Front 2

Antidote used for tricyclic antidepressants (TCA)

Back 2

Sodium bicarbonate

Front 3

Antidote used for carbon monoxide poisoning

Back 3

100% O2 and hyperbaric O2

Front 4

Antidote used for digitalis toxicity

Back 4

Digibind
(also need to d/c digoxin, normalize K+, and give lidocaine if pt. is arrhythmic)

Front 5

Antidote used for beta agonist toxicity (eg. Metaproterenol)

Back 5

Esmolol

Front 6

Antidote for methotrexate toxicity

Back 6

Leucovorin

Front 7

Antidote for beta-blockers and hypoglycemia

Back 7

Glucagon

Front 8

Antidote useful for some drug induced Torsade de pointes

Back 8

Magnesium sulfate

Front 9

Antidote for hyperkalemia

Back 9

sodium polystyrene sulfonate (Kayexalate)

Front 10

Antidote for salicylate intoxication (2)

Back 10

Alkalinize urine, dialysis

Front 11

Cancer Chemotherapy

Front 12

Constant proportion of cell population killed rather than a constant number

Back 12

Log-kill hypothesis

Front 13

Treatment with cancer chemotherapy at high doses every 3-4 weeks, too toxic to be used continuously

Back 13

Pulse therapy

Front 14

Toxic effect of anticancer drug can be lessened by rescue agents

Back 14

Rescue therapy

Front 15

Drug used concurrently with toxic anticancer agents to reduce renal precipitation of urates

Back 15

Allopurinol

Front 16

Pyrimidine analog that causes "Thymine-less death" given with leucovorin rescue

Back 16

5-fluorouracil (5-FU)

Front 17

Drug used in cancer therapy causes Cushing-like symptoms

Back 17

Prednisone

Front 18

Side effect of Mitomycin

Back 18

SEVERE myelosuppression

Front 19

MOA of cisplatin

Back 19

Alkylating agent

Front 20

Common toxicities of cisplatin

Back 20

Nephro and ototoxicity

Front 21

Analog of hypoxanthine, needs HGPRTase for activation

Back 21

6-mercaptopurine (6-MP)

Front 22

Interaction with this drug requires dose reduction of 6-MP

Back 22

Allopurinol

Front 23

May protect against doxorubicin toxicity by scavenging free radicals

Back 23

Dexrazoxane

Front 24

Blows DNA (breaks DNA strands), limiting SE is pulmonary fibrosis

Back 24

Bleomycin

Front 25

Bleomycin+vinblastine+etoposide+cisplatin produce almost a 100% response when all agents are used for this neoplasm

Back 25

Testicular cancer

Front 26

ABVD regimen used for HD, but appears less likely to cause sterility and secondary malignancies than MOPP

Back 26

Adriamycin (doxorubicin) +bleomycin, vinblastine +dacarbazine

Front 27

Regimen used for non-Hodgkin's lymphoma

Back 27

CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) plus rituximab

Front 28

Regimen used for breast cancer

Back 28

CMF (cyclophosphamide, methotrexate, and fluorouracil) and tamoxifen if ER+

Front 29

Alkylating agent, vesicant that causes tissue damage with extravasation

Back 29

Mechlorethamine

Front 30

Anticancer drug also used in RA, produces acrolein in urine that leads to hemorrhagic cystitis

Back 30

Cyclophosphamide

Front 31

Prevention of cyclophosphamide induced hemorrhagic cystitis

Back 31

Hydration and mercaptoethanesulfonate (MESNA)

Front 32

Microtubule inhibitor that causes peripheral neuropathy, foot drop (eg. ataxia), and "pins and needles" sensation

Back 32

Vincristine

Front 33

Interact with microtubules (but unlike vinca which prevent disassembly of tubules), it stabilizes tubulin and cells remain frozen in metaphase

Back 33

Paclitaxel (taxol)

Pacman eats and they Freeze

Front 34

Toxicities include nephrotoxicity and ototoxicity, leading to a severe interaction with aminoglycosides

Back 34

Cisplatin

Front 35

Agent similar to cisplatin, less nephrotoxic, but greater myelosuppression

Back 35

Carboplatin

Front 36

Converts asparagine to aspartate and ammonia, denies cancer cells of essential AA (asparagine)

Back 36

L-asparaginase

Front 37

Used for hairy cell leukemia; it stimulates NK cells

Back 37

Interferon alpha

I Found A hairy patient

Front 38

Anti-androgen used for prostate cancer

Back 38

Flutamide (Eulexin)

Front 39

Anti-estrogen used for estrogen receptor + breast cancer

Back 39

Tamoxifen

Front 40

Aromatase inhibitor used in breast cancer

Back 40

Letrozole, anastrozole

Let Ana's aroma Taze you

Front 41

Newer estrogen receptor antagonist used in advanced breast cancer

Back 41

Toremifene (Fareston)

Front 42

Some cell cycle specific anti-cancer drugs (6)

Back 42

Bleomycin, vinca alkaloids,
antimetabolites (eg., 5-FU, 6-MP, methotrexate, etoposide)

Front 43

Some cell cycle non-specific drugs (6)

Back 43

Alkylating agents (eg., mechlorethamine, cyclophosphamide), antibiotics (doxorubicin, daunorubicin), cisplatin, nitrosourea

Front 44

Anti-emetics used in association with anti-cancer drugs that are 5-HT3 (serotonin receptor subtype ) antagonists

Back 44

Odansetron, granisetron

Front 45

Nitrosoureas with high lipophilicity, used for brain tumors

Back 45

Carmustine (BCNU) and lomustine (CCNU)

Front 46

Anticancer drug that produces disulfiram-like reaction with ethanol

Back 46

Procarbazine

Front 47

Endocrine drugs: hypothalamic and pituitary hormones

Front 48

Somatostatin (SRIF) analog used for acromegaly, carcinoid, glucagonoma and other GH producing pituitary tumors

Back 48

Octreotide

Front 49

Somatotropin (GH) analog used in GH deficiency (dwarfism)

Back 49

Somatrem

Front 50

GHRH analog used as diagnostic agent

Back 50

Sermorelin