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10 Cards in this Set
- Front
- Back
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MOA of local anesthetics (LA's)
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Block voltage-dependent sodium channels
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This may enhance activity of local anesthetics
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Hyperkalemia
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This may antagonize activity of local anesthetics
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Hypercalcemia
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Almost all local anesthetics have this property and sometimes require the administration of vasoconstrictors (ex. Epinephrine) to prolong activity
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Vasodilation
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Local anesthetic with vasoconstrictive property, favored for head, neck, and pharyngeal surgery
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Cocaine
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Longer acting local anesthetics which are less dependent on vasoconstrictors
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Tetracaine and bupivacaine
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These LA's have surface activity
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Cocaine and benzocaine
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Most important toxic effects of most local anesthetics
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CNS toxicity
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Commonly abused LA which has cardiovascular toxicity including severe hypertension with cerebral hemorrhage, cardiac arrhythmias, and myocardial infarction
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Cocaine
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LA causing methemoglobinemia
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Prilocaine
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