Pharm Oneliners Drugs With Important Actions On Smooth Muscle

Front 1

Disease caused by excess ergot alkaloids

Back 1

St. Anthony's Fire

Front 2

Endogenous substances commonly interpreted as histamine, serotonin, prostaglandins, and vasoactive peptides

Back 2

Autocoids

Front 3

Syndrome of hypersecretion of gastric acid and pepsin usually caused by gastrinoma; it is associated with severe peptic ulceration and diarrhea

Back 3

Zollinger-Ellison Syndrome

Front 4

Drug that causes contraction of the uterus

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Oxytocin

Front 5

Distribution of histamine receptors H1, H2, and H3

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Smooth muscle; stomach, heart, and mast cells; nerve endings, CNS respectively

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Prototype antagonist of H1 and H2 receptors

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Diphenhydramine and ranitidine, respectively

Front 7

1st generation antihistamine that is highly sedating

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Diphendydramine

Front 8

1st generation antihistamine that is least sedating

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Chlorpheniramine or cyclizine

Front 9

2nd generation antihistamines

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Fexofenadine, loratadine, and cetirizine

Front 10

Generation of antihistamine that has the most CNS effects

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First generation due to being more lipid-soluble

Front 11

Major indication for H1 receptor antagonist

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Use in IgE mediated allergic reaction

Front 12

Antihistamine that can be used for anxiety and insomnia and is not addictive

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hydroxyzine (Atarax)

Front 13

H1 antagonist used in motion sickness

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Dimenhydrinate, meclizine, and other 1st generation

Front 14

Most common side effect of 1st generation antihistamines

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Sedation

Front 15

Lethal arrhythmias resulting from concurrent therapy with azole fungals (metabolized by CYP 3A4) and these antihistamines which inhibit the 3A4 iso-enzyme.

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Terfenadine and astemizole (have been removed from the market)

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H2 blocker that causes the most interactions with other drugs

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Cimetidine

Front 17

Clinical use for H2 blockers

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Acid reflux disease, duodenal ulcer and peptic ulcer disease

Front 18

Receptors for serotonin (5HT-1) are located

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Mostly in the brain, and they mediate synaptic inhibition via increased K+ conductance

Front 19

5HT-1d agonist used for migraine headaches

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Sumatriptan, naratriptan, and rizatriptan

Front 20

Triptan available in parenteral and nasal formulation

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Sumatriptan

Front 21

H1 blocker that is also a serotonin antagonist

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Cyproheptadine

Front 22

Agents for reduction of postpartum bleeding

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Oxytocin, ergonovine and ergotamine

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Agents used in treatment of carcinoid tumor

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Ketanserin cyproheptadine, and phenoxybenzamine

Front 24

5HT-3 antagonist used in chemotherapeutic induced
emesis

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Ondansetron, granisetron, dolasetron and alosetron

Front 25

5ht-3 antagonist that has been associated with QRS and QTc prolongation and should not be used in patients with heart disease

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Dolasetron

Front 26

DOC of chemo induced nausea and vomiting

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Odansetron

Front 27

Drug used in ergot alkaloids overdose, ischemia and gangrene

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Nitroprusside

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Reason ergot alkaloids are contraindicated in pregnancy

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Uterine contractions

Front 29

SE of ergot alkaloids

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Hallucinations resembling psychosis

Front 30

Ergot alkaloid used as an illicit drug

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LSD

Front 31

Dopamine agonist used in hyperprolactinemia

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Bromocriptine

Front 32

Peptide causing increased capillary permeability and edema

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Bradykinin and histamine

Front 33

Mediator of tissue pain, edema, inactivated by ACE, and may be a contributing factor to the development of angioedema

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Bradykinin

Front 34

Drug causing depletion of substance P (vasodilator)

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Capsaicin

Front 35

Prostaglandins that cause abortions

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Prostaglandin E1 (misoprostol) PGE2, and PGF2alpha

Front 36

Difference between COX 1 and COX 2

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COX 1 is found throughout
the body and COX 2 is only
in inflammatory tissue

Front 37

Drug that selectively inhibits COX 2

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Celecoxib and rofecoxib

Front 38

Inhibitor of lipoxygenase

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Zileuton

Front 39

Major SE of zileuton

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Liver toxicity

Front 40

Inhibitor of leukotrienes (LTD4) receptors and used in asthma

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Zafirlukast and montelukast

Front 41

Used in pediatrics to maintain patency of ductus arteriosis

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PGE1

Front 42

Approved for use in severe pulmonary HTN

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PGI2 (epoprostenol)

Front 43

Prostaglandin used in the treatment impotence

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Alprostadil

Front 44

Irreversible, nonselective COX inhibitor

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Aspirin

Front 45

Class of drugs that reversibly inhibit COX

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NSAIDS

Front 46

Primary endogenous substrate for Nitric Oxidase Synthase

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Arginine

Front 47

MOA and effect of nitric oxide

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Stimulates cGMP which leads to vascular smooth muscle relaxation

Front 48

Long acting beta 2 agonist used in asthma

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Salmeterol

Front 49

Muscarinic antagonist used in asthma

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Ipratropium

Front 50

MOA action of cromolyn

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Mast cell stabilizer

Front 51

Methylxanthine derivative used as a remedy for intermittent claudication

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Pentoxifylline

Front 52

MOA of corticosteroids

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inhibit phospholipase A2

Front 53

SE of long term (>5 days) corticosteroid therapy and remedy

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Adrenal suppression and weaning slowly, respectively