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9 Cards in this Set
- Front
- Back
Structurally related to acetylcholine, used to produce muscle paralysis in order to facilitate surgery or artificial ventilation. Full doses lead to respiratory paralysis and require ventialtion
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Neuromuscular blocking drugs
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These drugs strongly potentiate and prolong effect of neuromuscular blockade
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Inhaled anesthetics, isoflurane, AG, and antiarrhythmic
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These prevent the action of Ach at the skeletal muscle endplate to produce a surmountable blockade effect is reversed by cholinesterase inhibitors (ex. neostigmine or pyridostigmine)
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Nondepolarizing type of antagonist
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Agent with long duration of action and is most likely to cause histamine release
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Tubocurarine
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Non-depolarizing antagonist has short duration
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Mivacurium
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Agent can block muscarinic receptors
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Pnacuronium
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Agent undergoing Hofmann elimination breaking down spontaneously
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Atracurium
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One depolarizing blocker that causes continous depolarizing and results in muscle relaxation and paralysis. xcuses muscle pain postoperatively and myoglobinuria may occur
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Succinylcholine
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During Phase I these agents worsen the paralysis by succinylcholine, but during phase II they reverse the blockade produced by succinylcholine
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Cholinesterase inhibitors
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