Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
26 Cards in this Set
- Front
- Back
Aspirin
|
irreversible inhibition of COX inhibitor
RA and inflammatory diseases, anti-thrombolytic, antipyretic, nonspecfic analgesia Danger in G6PD deficiency, use with viral illness in children leads to Reyes syndrome follow zero order kinetics high does can decrease renal GFR and decrease gastric secretions and depress resp center excretion determined by pH of urine effect can last 7-8day |
|
Soduim Salicylate
|
COX inhibitor
|
|
Mesalamine
|
COX inhibitor
Tx of ulcerative colitis and Crohns contra in G6PD defiency and with viral illness in children due to risk of Reyes syndrome |
|
Sulfasalazine
|
inhibition of COX and LOX, IL-1 and TNF-alpha prod, radical scavenging, and inhibition of pro-inflammatory transcription factor NF-kB
tx for ulcerative colitiis and Crohns |
|
Ibuprofen
|
COX inhibitor, less prounouced effects than salicylates
decreased leukocyte migration anti-inflammatory effects only and doses over 2400mg/day tx for closure of patent ductus arterisos, knee osteoarthritis, postsurgical dental pain, safe in children with viral illness |
|
Flurbiprofen
|
COX inhibitor
tx for pre-op in minor ear, neck, and nose surgery |
|
Oxaprozin
|
|
|
Ketoprofen
|
COX inhibitor, less prounouced effects than salicylates
|
|
Naproxen
|
COX inhibitor, less prounouced effects than salicylates
decreased leukocyte migration |
|
Diclofenac
|
COX inhibitor, low lvl of LOX inhibition
larger anti-inflammatory, but less analgesic |
|
Ketorolac
|
COX inhibitor
huge analgesic effect, less anti-inflammatory can suppliment morphine and/or lower the opoid requirement Tx of post op pain |
|
Sulindac
|
COX inhibitor, can induce Stevens-Johnson syndrome
|
|
Piroxicam
|
COX-1 > COX-2 inhibitor, one of the most effective COX-inhibitors
50hr half life allowing for daily dosing |
|
Meloxicam
|
COX-1 > COX-2 inhibitor
50hr half life allowing for daily dosing tx for osteoarthritis |
|
Indomethacin
|
most potent inhibitor of COX, decreases ecoisaniod prod, PMN migration, and T/B cell proliferation
closure of patent ductus arteriosus, acute gout, joint pain contra in PREG mostly used for anti-inflammatory effect, as analgesic effect is close to toxic dose Contra with probenecid coadmin!!! and Contra in 3rd tri PREG |
|
Celecoxib
|
COX-2 inhibitor, good anti-inflammatory with little GI effect
Tx of RA FDA black box with cardiovascular risk |
|
Acetaminophen
|
inhibition of COX, strong in CNS, weak in periphery, so little anti-inflammatory. Does NOT affect platelets.
danger with p450 inducers or EtOH due to formation of NAPQI Tx overdose with NAC (N-acetylcysteine) Tx for fever, mild pain. Safe for kids |
|
Cortisone
|
short-acting glucocorticoid
|
|
Hydrocortisone
|
short-acting glucocorticoid
|
|
Methylprednisolone
|
short-acting glucocorticoid
|
|
Prednisolone
|
short-acting glucocorticoid
|
|
Prednisone
|
short-acting glucocorticoid, admin as a pro-drug
|
|
Triamicinolone
|
intermediate-acting glucocorticoid
|
|
Bethamthasone
|
long-acting glucocorticoid
|
|
Dexamethasone
|
long-acting glucocorticoid
|
|
Glucocorticoids
|
bind to transcription factors to create wide spread effects
anti-inflammatory, immunosuppressive, adrenalcortical insufficiency, postop in Cushings, stim of fetal lung maturation, mediate allergic rxns, AE are many, so monitoring is needed |