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8 Cards in this Set
- Front
- Back
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Cistaracurium
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Neuromuscular blocker
curare-like drug Indication: no dose adjustment needed for renal failure (b/c of spontaneous inactivation) |
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Vecuronium
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Neuromuscular blocker
Aminosteroids RAPID onset (< 1 min) Biliary elimination (one cation - 1+; renal elimination usually with 2+) |
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How do you reverse non-depolarizing neuromuscular blockades?
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inhibiting Acetylcholinesterase (-stigmines) raises Ach levels at synapse which will overcome the competitive antagonists.
At high doses, cannot overcome = respiratory collapse |
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Baclofen
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GABAb receptor agonist
Muscle spasticity CNS interneuron Inhibits Glutamate release from an excitatory neuron Risk: seizures, withdrawals |
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Diazepam
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GABAa agonist
Muscle spasticity potentiates GABA (inhibitory NT) Risk: abuse potential |
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Dantrolene
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Ryanodine receptor antagonist
Muscle spasticity Doesn't allow Ca out of SR = no muscle contraction Risk: hepatotoxicity |
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Carisoprodol
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Muscle spasm agent
Polysynaptic inhibitor High abuse potential |
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Cyclobenzaprine
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Muscle spasm agent
Polysynaptic inhibitor tricyclic anti-depressant analog (seritonin syndrome) |
