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14 Cards in this Set
- Front
- Back
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What is an important difference between azithromycin and clarithomycin?
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Azithromycin does not interfere with metabolism of CYP450
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Macrolides: list
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Azithromycin
Clarithomycin |
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Macrolides: mechanism
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Binds to 50S ribosome-->inhibits translocation of peptidyl tRNA-->inhibits translation
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Macrolides: administration
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IV or oral
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Clindamycin: administration
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Oral, IV/IM
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Clindamycin: mechanism
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Bind to 50S ribosomal unit
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Synercid (quinopristin/dalfopristin)-administration
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IV only
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Synercid (quinopristin/dalfopristin): mechanism
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Bind to 50S subunit of ribosome
Work synergistically to kill bacteria |
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Linezolid: administration
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IV and oral
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Linezolid: mechanism
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Prevents formation of 70S (both subunits) by binding to 50S subunit
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Daptomycin: administration
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IV
Poorly absorbed by PO |
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Daptomycin: mechanism
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Binds to bacterial membranes-->depolarization and loss of membrane potential-->cell death
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Vancomycin: administration
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IV
Poor GI absorption |
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Vancomycin: mechanism
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Inhibits cell wall synthesis-->bind to precursor of peptidoglycans-->no cell wall formation or cross linking
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