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10 Cards in this Set

  • Front
  • Back
What is the chemical structure of anesthetics?
an aromatic group linked to an amine
what types of bonds are found in anesthetics?
- ester bond
- amide bond
list ester anesthetics
- procaine
- tetracaine
- benzocaine (topical)
- cocaine (vasoconstrictor)
list amide anesthetics
- bupivicaine
- lidocaine
- mepivacaine
- etidocaine
what is the hydrophobicity of the molecule determined by?
the alkyl substituents on the amine
where do local anesthetics bind?
to Na channels from the inside of the membrane
- bind to inactive and open channels which predominate in the depolarized state
what is use-dependent blockade?
prefer to bind to inactive and open Na channels wich predominate in depolarized states.
what is so good about use-dependent blockade?
only targets diseased myocytes (cardiac arrhythmias) and pain neurons (which fire more during pain sensations
what can you use to treat arrhythmia in the heart?
where are nocireceptor cell bodies located?
- DRG or in trigeminal ganglion for facial innervation