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8 Cards in this Set

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list the H1 blockers
- diphenhydramine
- chlorpheniramine
- promethazine
- terfenadine
- fexofenadine
what are H1 blockers used for?
- control hypersensitivity reactions
- anticholinergic side effects
- terfenadine (prodrug- causes arrthymias) --> fexofenadine
which anticholinergic side effects are caused by H1 blockers?
- urinary retention
- tachycardia
- mydriasis
- xerostomia (dry mouth)
list the H2 blockers
- cimetidine
- ranitidine
- famotidine
what are H2 blockers used for?
- gastric ulcers
how does cimetidine work?
cimetidine is a H2 blocker.
- it is a P450 inhibitor
- limits metabolism of estrogen --> hyperestrinism --> gynecomastia --> spider angiomata
where do you find spider angiomatas?
cimetidine is a P450 inhibitor. It raises estrogen levels
in pregnant women and in people with liver disease (high estrogen levels)
what can you use instead of H2 blockers?
PPIs (omeprazole) which last longer since they covalently inhibit the H/K/ATPase