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11 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Isoniazid
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TB prophylaxis and Tx when combined with other TB drugs
inhib mycolic acid |
Liver damage (esp in slow acytelators)
Hemolysis c G6PD def Peripheral neuropathy Lupus-like effects use extreme caution in pts >35 |
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Rifampin
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TB Tx in combo c other TB drugs
Leprosy Tx DNA-dependent RNA polymerase activity G+ cocci, some G- |
P450 inducer
Orange secretions |
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Ethambutol
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TB Tx in combo c other TB drugs
inhibits arabinosyl transferase |
Low toxicity
decreased visual acuity and Loss of Reg-Green perception |
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Pyrazinamide
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TB Tx in combo c other TB drugs
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Highly Toxic
hepatic injury |
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Ethionamide
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secondary TB Tx
oral |
Neurological complications
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Cycloserine
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secondary TB Tx
oral |
peripheral neuropathy
psychotic reactions |
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Capreomycin
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secondary TB Tx
IM |
Kidney, damage
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Rifabutin
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secondary TB Tx
oral derivative of Rifampin also for MAC and leprosy |
rash
urine discoloration thrombocytopenia |
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Dapsone
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DOC: Leprosy
PABA antagonist |
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Clofazimine
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binds Mycobacterial DNA and prevents reproduction
30 days for steady state in blood |
hepatitis
Crystalline deposits in tissues |
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Thalidomide
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Tx: erythema nodosum leprosum, increases lean body mass in AIDS pts
degradation of TNF-alpha mRNA |
teratogenisis
drowseyness, constipation peripheral neuropathy rash |
