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18 Cards in this Set
- Front
- Back
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Prostaglandins function
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can cause smooth muscle contraction or relaxation;
inhibit gastric secretion; PGE cause pain when injected intradermally INDUCE LABOR RENAL SALT & WATER EXCRETION ; increases renal blood flow Can vasodialate or vasoconstrict |
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A term used to point out a characteristic of a person. (Swift-footed Achilles) Can be abusive, or offensive, but are not so by definition. (The Rock, Jake "the Snake")
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epithet
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Prostacyclin fxn
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Inhibits platelet aggregation
Vasodialates INHIBITS GASTRIC SECRETION Sensitive to pain |
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Leukotriene fxn
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CAUSE HYPOTENSION;
Cause anaphylaxis (s.m. constriction) Bronchoconstriction Chemotactic |
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When are Prostaglandins formed?
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Under inflammatory conditions causing pain and vasodialation
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Aspirin MOA
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Aspirin irreversibly and non-selectively inhibits fatty acid cyclo-genases,
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Apsirin properties
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antipyretic
Analgesia (blocks pain) Anti-inflammatory Uncouples oxidative phosphorylation |
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FDA indications for aspirin
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. Cerebrovascular accident; prophylaxis b. Fever c. Generalized aches and pains d. Headache e. Migraine f. Myocardial infarction g. Myocardia infarction; Prophylaxis h. Osteoarthritis i. Pain j. Rheumatoid arthritis
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Aspirin Adverse effects
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1) Gastric Irritant (blocks prostacyclin & prostaglandin)
2)Hypersensitivity --> anaphylaxis (b/c pushing toward more leukotrienes??) --> nasal polyps = risk factor |
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Aspirin toxicity
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Salicylism and RENAL toxicity?
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What is Substituted Acetic Acid?
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Indomethacin - one of the most potent inhibitors of fatty acid cyclo-oxygenase thus
inhibiting prostaglandin, thromboxane and prostacyclin synthesis. |
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FDA uses for Indomethacin
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1) Ankylosing spondylitis*
2) Gouty arthritis, acute* 3) Osteoarthritis 4) Pain 5) Patent ductus arteriosis* 6) Barter's syndrome 5) RA* |
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Toxicity of Indomethacin
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gastro-intestinal complaints hypersensitivity - usually shows cross-reactivity with aspirin CNS effects - headache, vertigo, somnolence
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What are propionic acid deritvatives?
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1) Ibuprofen
2) Naproxen The proprionic acid derivatives are usually better tolerated than aspirin, indomethacin and the pyranzolones. They are inhibitors of cyclo-oxygenase. They can produce aspirin- like hypersensitivity. |
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Ketorolac Tromethamine
Pharmokinetics? |
1) injection
2) plasma bound protien 3) TRANSPLACENTAL!!! NOT FOR PREGNANT WOMEN!!!! 4) RENAL CLEARANCE |
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FDA label indications for Ketorolac
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1) Extraction of cataract-Inflammatory disorder of the eye
2) Pain, Short term 3) Pain in eye- Refractive keratoplasty 4)Seasonal allergic conjunctivitis |
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MOA of Celecoxib?
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Selective for COX II
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PHARMACOKINETICS for Celecoxib
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a. absorption decreased by food b. effective t1/2 = 11 hours
c. high plasma protein binding d. metabolized by CYP 2C9 |
