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9 Cards in this Set
- Front
- Back
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Why are log scales popular in pharmacology?
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The log-scale dose-response curves tend to accentuate the the more interesting elements of the curve.
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What are three ways to express the potency/apparent affinity of a drug?
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EC50 - the effective concentration, 50%
Kd - the apparent dissociation constant of the drug IC50 - inhibitor/antagonist conc'n. at 50% reduction of activity |
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If a drug's Kd and EC50 are the same molar amount, what does it say abou the receptor population being studied?
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When Kd = EC50, the receptors are 100% bound.
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How is Kd defined?
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Kd = ( [D] * [R] ) / [DR] = k2/k1
* k2 = dissociation rate * k1 = association rate |
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What are three major components of drug action?
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1) Route of administration
2) Receptor affinity 3) Effect of receptor/ligand interaction |
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How is a competitive antagonist defined?
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Competitive antagonists have all the accessibility and affinity, but none of the intrinsic activity.
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When does an agonist become an antagonist?
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Partial agonists become antagonistic when introduced against full-fledged agonists.
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What drug constant forms the basis for therapeutic selectivity?
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A drug's Kd across a spectrum of receptors will determine its therapeutic selectivity in the body.
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What are spare receptors?
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If a receptor pool has yet to saturate, but has reached its maximum response rate, any additional receptors in the pool are said to be "spare." Additional drug/ligand pairs will not enhance the response.
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