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28 Cards in this Set

  • Front
  • Back
Arachinodic acid produces?
Thromboxanes
Leukotrienes
Prostaglandins
Cyclooxygenase pathway converts arachinodic acid to?
Prostaglandins
Thromboxanes
Arachidonic acid is converted to leukotrienes by?
5-lipooxygenase enzyme
Irreversibly inhibits COX (thromboxane production in platelets)
ASA
T/F All NSAIDS are reversible except for ASA
TRUE
How does ASA affect the respiratory system?
causes hyperventilation and respiratory alkalosis at high doses
How does ASA affect the Kidney?
causes sodium and water retention and edema
Can induce renal failure
what are the uses of ASA?
Reduces fever, pain, inflammation

Decrease pain of HA, arthralgias, myalgias, RA

Reduces platelet aggregation
what are the side effects of ASA
GI Bleed
Prolongs bleeding time
Resp depression
Resp and metabolic acidosis
Hypersensitivity – inhibiting leukotrienes (leukotrienes inhibit histamine release)
What is the Tx of ASA toxicity?
Increase urine pH to hasten renal elimination
IV fluids, dialysis, and correction of acid-base and electrolyte disturbances
Name some NSAIDS
Salicylates
Proprionic Acid Derivatives
Acedic Acid Derivatives
Enolic Acids
Non-Acidic Compounds
COX-2 Inhibitors- Celebrex
what are the adverse effects of Indomethacin (indocin)
GI
Acute Pancreatitis
Neutropenia
Thrombocytopenia
Allergic Reactions
Motrin, Advil, and Nuprin all contain?
Ibuprofin
this drug is indicated for the short-term (up to 5 days in adults) management of moderately severe acute pain that requres analgesia at the opioid level
Ketoralac (Toradol)
What are the contra-indications of Ketoralac (Toradol)
Renal impairement
Epidural patients
ASA allergic
Name a COX-2 Inhibitor
Celebrex
what are the actions of Celebrex?
Anti-inflammatory
Analgesic
Antipyretic
What are the indications of Celebrex?
Osteoarthritis
RA
What are the ddverse efffects of Celebrex?
GI: N/V/D
Edema
This drug has no effect on platelets (no cardio protective effects)
No anti-inflammatory effects
Acetaminophen (APAP, Tylenol)
What is the max dose of Tylenol?
4gms per day
Where is ASA best absorbed?
In the stomach
Can ASA cross the BBB?
YES
Name some salycilates
ASA
Choline Magnesium Trisalicylate (Trilisate)
Diflunisal (Dolobid)
Salsalate (Disalcid)
Name 2 enolic acids
Meloxicam (Mobic)
Piroxicam (Feldene)
What is the DOC for a gouty arthritis attack?
Indomethacin (Indocin)
IV NSAID
Ketoralac (Toradol)
What are the indications of COX-2 (Celebrex)?
Osteoarthritis
Rheumatoid arthritis