Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/48

Click to flip

48 Cards in this Set

  • Front
  • Back
Which organisms are best treated with 1st Gen. Cephs?
PEK

Proteus mirabilis
E.Coli
Klebsiella
What is the DOC for Klebsiella?
1st Gen. Ceph
What is the treatment for UTI?
Uncomplicated- Bactrim x 3 days
Recurrent- 2-6 wks
If allergic to PCN or Cephs, what would you give for surgical prophylaxis?
Vancomycin, but not for ab surgery
which drugs are good for prophylaxis in abdominal surgery
Metal Tan Fox:

Cefmetazole
Cefotetan
Cephoxitin

They have mixed anaerobe and aerobe coverage
What are 2nd Gen. Cephs good for?
HEN PEK

H.Flu
Enterobacter
Neisseria

Proteus mirabilis
E.Coli
Klebsiella
T/F Cephs are good for treating enterococcus
False
Name 2 second gen. cephs that have anaerobe-aerobe coverage
Cefoxitin
Cefotetan
What is the only IV 2nd gen ceph?
Cefuroxime (Ceftin)
what's the DOC for meningitis and gonorrhea?
Ceftriazone (rocephin)
what is the dose for meningitis?
Rocephin 2gm Q12 IV only
What are 3rd gen. cephs used for?
For more serious infections of: PEEK

Proteus
E.Coli
Enterobacter
Klebsiella
Which cephs are effective against pseudomonas?
Ceftriaxone/Ceftazidime(BBB)
Cefoperazone
Cefipime
Which ceph has the longest half-life?
Ceftriaxone 14-24 hrs

Once a day, except with meningitis
what is the chance of being allergic to Cephs if you're allergic to PCN? If you're not allergic?
Allergic: 15% chance
No allergy: 3% chance
what is Cefipime good for?
Resistant organisms
ESBL pneumonias or UTIs(PCNs don't work)
Which is the last resort Beta-lactam?
Carbapenems:

Primaxin IV only
T/F Primaxin is nephrotoxic
TRUE: dose adjust with renal patients
which is the broades spectrum of all beta lactams?
Primaxin
T/F Primaxin lowers seizure threshold
TRUE
when would you use a monobactam (Aztreonam)?
Use with pen/ceph allergic patient to treat gram - organism
What's the MOA of Vancomycin?
Inhibits cell wall synthesis
What is Vancomycin used for?
MRSA
what is the dose for Vanco?
15mg/kg (use actual body wt)

If CrCl is <50, Q24
If CrCl is >50, Q12
what do you monitor with Vanco?
Trough: take half hr before 3rd dose to see if pt is eliminating the drug (watch for nephrotoxicity)
what should the troughs be with Vanco?
10-15

15-20 when more penetration is needed:
Endocarditis
Lung infection
Septic with multiple organ failure
when would you get a peak and a trough with vanco?
With patients where they're volume is constantly changing

Dialysis patient
Burn patients
Elderly patients
Septic patients
What is the treatment for C.Diff?
Vancomycin orally or
Flagyl
If troughs are increased what do you do?
Increase the dosing interval

Ex: Go from Q12 to Q24

If troughs are decreased do the opposite
What products should you avoid when taking TCN?
Dairy products
What is TCN used for?
First line agent for:

Cholera
Chlamydia
Mycoplasma
Lyme Disease
Rocky mountain spotted fever
where does TCN concentrate?
Liver
Kidney
Spleen
Teeth
Bone
Name the AGs
Neomycin
Gentamycin
Tobramycin
Streptomycin
Amikacin
What is the MOA of AGs?
inhibits protein synthesis
T/F AGs are renally excreted
TRUE
what is the dosing for Gentamycin or Tobramycin
5mg/kg Q24

With obese patients, use obese dosing weight
What do you monitor with AGs?
Peaks and troughs
T/F Nephrotoxicity from AGs is reversible
TRUE

Ototoxicity is NOT
Which is the most toxic AG?
Neomycin
How do you treat pseudomonal infections?
AG plus a beta-lactam
Your patient is scheduled for abdominal surgery, what do you use to sterilize the gut?
Oral neomycin 3 doses 2 days prior to surgery
What is the MOA of quinolones?
Inhibit DNA synthesis
What are FQ used for?
Gram +/-

Cipro and levoquin also have pseudomonal coverage
What are the clinical uses of FQ?
UTI
URI & LRI
Osteomyelitis
Prostatic infection
Which drug decreases FQ clearance?
Theophylline
Should FQ be taken on an empty stomach?
Yes, food delays absorption
Which drugs can cause Pseudomembraneous colitis?
Ampicillin
Clindamycin
Name some side effects of FQs
Cartilage damage(retards growth in kids)
CNS disturbances
N/V
Skin Rash
Prolongs QT