Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
7 Cards in this Set
- Front
- Back
|
Cyclosporine (CSA)
|
binds to cyclophilins--> inhibits calcineurin-->prevents IL-2 and receptor production
tox: viral infections, lymphoma; nephrotoxic (prevent with mannitol) |
|
|
Tacrolimus (FK506)
|
binds to FK-binding protein --> inhibits calcineurin --> prevents IL-2/receptor production
tox: nephrotoxicty, periph. neuropathy, HTN, pleural effusion, hyperglc |
|
|
Azathioprine
|
6-MP antimetabolite precursor. toxic to prolif lymphocytes. interferes with synthesis of nucleic acids.
use: kidney tx, autoimmune. tox: BM suppression, allopurinol can increase mercaptopurine |
|
|
Muromonab-CD3 (OKT3)
|
Monoclonal Ab binds to CD3 on T cells
use: kidney tx tox: cytokine release. hypersensitivity rxn. |
|
|
Sirolimus (rapamycin)
|
binds to FK-binding protein --> binds to mTOR --> inhibits T-cell proliferation in response to IL-2
use: +CSA, steroids for kidney tx. tox: HL, thromboxytopenia, leukopenia |
|
|
Mycophenolate mofetil
|
inhibits de novo guanine synthesis.
blocks lymphocyte production. |
|
|
Daclizumab
|
monoclonal Ab with high affinity for IL-2 receptor on activated T cells
|
