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23 Cards in this Set

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prednisone
corticosteroid effects transcription of arachidonic producers
prenisolone
corticosteroid, effects transcription of arachidonic producers
cyclosporine
immunosuppressant, inhibits interleukin 2 transcription, inhibits T cell activation
tacrolimus (F506)
immunosuppressant, 100Xs more potent than cyclosporine, inhibits interleukin 2 transcription, inhibits T cell activation
sirolimus
immunosuppressant, inhibits T cell activation and T cell proliferation
azathioprine
cytotoxic, purine antimetabolite, competitive inhibitor of inosinic acid, blocks T cell proliferation more than B cell, arrests them in DNA synthesis protion of cell cycle
mycophenolate
cytotoxic, inhibition of inosine monophosphate dehydrogenase, blocks B and T cell proliferation
cyclophosphamide
cytotoxic, alkylating agent
methotrexate
cytotoxic, anti-metabolite
FTY720
sphingosine 1-phosphate receptor agonist (SIP-R), sequesters lymphocytes in lymph node and peyer's patch. protects grafts from T cell mediated attack.
antithymocyte globulin (ATG)
antibody, purified immunoglobin from horses, removes T cells from blood, spleen, and lymph nodes
immune globin
antibody, human plasma from hyperimmunized donors
orthoclone OKT3
antibody, mouse monoclonal antibody, binds CD3 and blocks antigen recognition complex on T cells, T cells unable to recognize foreign antigen
basiliximab
antibody, mouse/human, anti-IL2, blocks receptor on T cells
daclizumab
antibody, mouse/human, anti-IL2, blocks receptor on T cells
infliximab
antibody, binds TNF alpha receptor on T cells
etanercept
antibody, binds TNF alpha receptor on T cells
Rh o (D) immune globin (Rhogan)
antibody, anti-D or Rh, block antibody responxe of Rh negative mother to a Rh positive baby
bacillus calmette-guerin (BCG)
immunostimulant, viable attenuated strain of myobacterium bovis, T cells and natural killers stimulated
thymic factor
immunostimulant, promote T cell and early stem cells differentiation
interleukin 2
immunostimulant, promotes prolif, differentiation, and recruitment of T and B cells, natural killers, and thymocytes
granulocyte macrophage colony stimulating factor (GM-CSF)
immunostimulant, cytokines that stimulate the clonal expansion and differentiation of granulocytes and macrophages
granulocyte colony stimulating factor (G-CSF)
immunostimulant, cytokines that stimulate the clonal expansion and differentiation of granulocytes