Pharm - Immuno

Front 1

This drug binds to cyclophilins, blocking differentiation and activation of T cells mainly by inhibiting IL2 production

Back 1

cyclosporine

Front 2

This antimetabolite derivative of 6-mercaptopurine interferes with the metabolism and synthesis of nucleic acid, therefore toxic to proliferating lymphocytes

Back 2

azathioprine

Front 3

This potent immunosuppressive drug binds to the FK-binding protein and inhibits secretion of IL2 and other cytokines

Back 3

tacrolimus (FK506)

Front 4

This drug is used to suppress organ rejection after transplantation, but may predispose patient to viral infections and lymphoma

Back 4

cyclosporine

Front 5

Azaothioprine is used to in what setting?

Back 5

Kidney transplants, autoimmune disorders (glomerulonephritis, hemolytic anemia)

Front 6

Recombinant Cytokine- Aldesleukin (interleukin-2) is used for?

Back 6

Renal cell carcinoma, metastatic melanoma

Front 7

Recombinant Cytokine- Erythropoietin (epoetin) is used for?

Back 7

anemia

Front 8

Recombinant Cytokine- Filgrastim is used for?

Back 8

Recovery of Bone Marrow; it is a granulocyte colony stimulating factor

Front 9

Recombinant Cytokine- alpha interferon is used for?

Back 9

Hep B/C, Kaposi's sarcoma, leukemia, malgnant melanoma

Front 10

Recombinant Cytokine- beta interferon is used for?

Back 10

Multiple Sclerosis

Front 11

Recombinant Cytokine- gamma interferon is used for?

Back 11

Chronic Granulomatous disease

Front 12

Recombinant Cytokine- oprelvekin (interleukin2) is used for?

Back 12

Thrombocytopenia

Front 13

Recombinant Cytokine- sargamostim is used for?

Back 13

Recovery of Bone Marrow (it is a granulocyte-macrophage colony stimulating factor)

Front 14

Recombinant Cytokine- thrombopoietin is used for?

Back 14

Thrombocytopenia

Front 15

Corticosteroids

Back 15

466

Front 16

Mech of axn?

Back 16

Dec synth of PG, LT, cytokines; inh T cell prolif; lowers IgG chronic

Front 17

Use?

Back 17

Immunosuppression

Front 18

Main tox? 6

Back 18

Adrenal suppresion, growth inh, muscle wasting, osteoporosis, salt retention, glucose intolerance

Front 19

Cyclosporine

Back 19

466

Front 20

Mech of axn? 3

Back 20

Binds cyclophilin; lower T cell response to activation; inh calcineurin

Front 21

Use? 3

Back 21

solid organ transplant; GVHD; autoimmune dz

Front 22

Tox? 5

Back 22

Renal dysfxn, HTN, neurotox, hyperglycemia, hyperlipidemia

Front 23

Tacrolismus

Back 23

466

Front 24

Mech of axn? 3

Back 24

Binds FKBP lower T cell response to activation; inh calcineurin

Front 25

Use? 3

Back 25

solid organ transplant; stem cell transplant; GVHD

Front 26

Tox? 5

Back 26

Renal dysfxn, HTN, neurotox, hyperglycemia, hyperlipidemia

Front 27

Sirolimus

Back 27

466

Front 28

Mech of axn? 2

Back 28

Binds FKBP lower T cell response to activation

Front 29

Use? 1

Back 29

Solid organ transplant with cyclosporine

Front 30

Tox? 4

Back 30

hypertriglyceridemia, hepatotox, diarrhea, myelosuppression

Front 31

Mycophenolate mofetil

Back 31

467

Front 32

Mech of axn? 1

Back 32

Inh de novo purine synth

Front 33

Use? 3

Back 33

Sole agent in kidney, liver, heart transplant

Front 34

Tox? 3

Back 34

GI, myelosuppression, esp neutropenia

Front 35

Azathioprine

Back 35

467

Front 36

Mech of axn? 1

Back 36

Inh purine metabolism

Front 37

Prodrug to?

Back 37

Mercaptopurine

Front 38

Use? 2

Back 38

Autoimmune dz; immunosuppression for renal homograft

Front 39

Tox? 2

Back 39

myelosuppression; incr incidence of CA

Front 40

Cyclophosphamide

Back 40

467

Front 41

Mech of axn?

Back 41

Inh B > T

Front 42

Use? 3

Back 42

Autoimmune dz; Ab-induced RBC aplasia; bone marrow transplant

Front 43

Tox? 4

Back 43

Pancytopenia, GI, hemorrhagic cystitis, alopecia

Front 44

ALG, ATG

Back 44

468

Front 45

Mech of axn? 1

Back 45

Initiate T cell destruction by complement

Front 46

Use? 1

Back 46

before bone marrow transplant

Front 47

Tox? 1

Back 47

HSR

Front 48

Rho(D) Ig

Back 48

468

Front 49

Mech of axn? 1

Back 49

Blocks primary imm response to foreign cells

Front 50

Use? 1

Back 50

Prevent HDNB

Front 51

Muromonab-CD3

Back 51

468

Front 52

Mech of axn?

Back 52

Mab to CD3; kill CTL

Front 53

Use? 1

Back 53

Manage renal transplant

Front 54

Tox? 2

Back 54

HSR, 1st dose fx

Front 55

Daclizumab

Back 55

468

Front 56

Mech of axn?

Back 56

Mab to IL-2

Front 57

Use? 1

Back 57

Prevent renal rejection

Front 58

Tox? 1

Back 58

same as placebo

Front 59

Infliximab

Back 59

468

Front 60

Mech of axn?

Back 60

Mab to TNF-a

Front 61

Use? 5

Back 61

Crohn's disease; RA; UC; ankylosing spondylitis; psoriatic arthritis

Front 62

Tox? 2

Back 62

infusion rxn; incr infections

Front 63

Aldesleukin

Back 63

468

Front 64

Mech of axn?

Back 64

Recomb IL-2

Front 65

Use? 2

Back 65

Renal cell CA; malig melanoma

Front 66

IFN

Back 66

469

Front 67

Mech of axn? 4

Back 67

Anti-viral by:
Promote mRNA degradation
Inh viral protein synth
Incr MHC I, II expression & Ag presentation
Activate NK to kill virus-infected cells

Front 68

Use? 7

Back 68

HCL, CML, malig melanoma, Kaposi's, HBV, HCV, MS

Front 69

Etanercept

Back 69

467

Front 70

Mech of axn?

Back 70

Recomb TNF-R

Front 71

Use? 2

Back 71

RA, psoriatic arthritis

Front 72

Tox? 3

Back 72

infusion rxn; HSR; incr inf

Front 73

Leflunomide

Back 73

467

Front 74

Mech of axn? 2

Back 74

inh pyriidine synth; arrest lymphocytes in G1

Front 75

Use?

Back 75

RA, psoriatic arthritis

Front 76

Tox? 4

Back 76

hepatotox, nephrotox, teratogen, CVS

Front 77

Thalidomide

Back 77

467

Front 78

Mech of axn? 3

Back 78

Suppress TNF, incr IL-10, etc

Front 79

Use? 2

Back 79

Leprosy, anti-CA

Front 80

Tox? 1

Back 80

Teratogen

Front 81

Alefacept

Back 81

467

Front 82

Mech of axn? 1

Back 82

Blocks CD2-R

Front 83

Use? 1

Back 83

Psoriasis

Front 84

Tox? 1

Back 84

Dose-dependent reduction T cells