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5 Cards in this Set

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What are the bile acid resins? (2)
Cholestyramine
Colesevelam
What is one of the mechanisms of action of bile acid resins?
Binds bile acids in the GI tract
DO NOT enter systemic circ
(+) bile acid excretion
(-) bile acid hepatic recirculation
What is one of the mechanisms of action of bile acid resins?
Enhances hepatic conversion of cholesterol to bile acids

cholestero---> 7a hydroxylase --> cholic acid
What is one of the mechanisms of action of bile acid resins?
Increases # of hepatic LDL recpetors
Therapeutic uses of bile acids
1. Hypercholesterolemia
2. peak effect at 4 wks
3. Ineffective for hypertriglyceridemia