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6 Cards in this Set
- Front
- Back
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In General Heavy Metals... |
1. cause enzyme inhibition 2. generate oxidative stress 3. alter gene expression |
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Lead sources of contamination, absorption routes, distribution |
1. glass, air, soil and water (plumbing) 2. skin, GI, respiratory 3. soft tissues: liver, brain and kidneys. Stored in bones. |
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Lead Clinical Effects Blood |
1. bound to RBC 2. induces anemia, interfere with heme synthesis ( aminolevulinic Acid Dehydratase and ferrochlatase) 3. increase RBC membrane fragility and decrease survival time |
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Lead Clinical Effects Nervous System |
most sensitive to damage - children: lower hearing, IQ, learning and behavioral - Adults: irritability, fatigue, sleep, libido, anorexia, slowed reaction time -lead encephalopathy - peripheral neuropathy: wrist drop |
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Lead Clinical Effects Reproductive System |
- premature, small babies with decrease mental and learning ability - miscarriage, lower gestational age - diminished or aberrant sperm in men |
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Lead Clinical Effects Kidneys and GI |
- fibrosis, nphr |
