Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/40

Click to flip

40 Cards in this Set

  • Front
  • Back
Phenytoin
- partial, tonic-clonic, status epilepticus
- >5y/o
- preferred for psychomotor w/ tonic-clonic
Phenobarbitol
- tonic-clonic, cortical focal, status epilepticus
- <5y/o
Carbamazepine
- partial, tonic-clonic
- preferred over phenytoin for girls and children
Gabapentin
- partial
- GABA analogue
Lamotrigine
- partial, tonic-clonic
Exhosuximide
- preferred for absence
- blocks T-type Ca channels
Valproate
- absence, tonic-clonic, cortical focal
- short t1/2
Diazepam & Lorazepam
- status epilepticus
- given IV
Vigabatrin
- inhibits GABA transaminase
Thiopental
- ultra-short acting
Morphine
- mu receptor
- for suffering, not perception
- dull pain better than sharp
- IV better than oral
Codeine
- methylmorphine
- mu receptor, lower affinity than morphine
- oral/IV ratio is high
- antitussive
Heroin
- morphine with acetyl groups instead of hydroxyl groups
- more lipophilic, enters CNS -> rush
Oxycodone
- oral/IV ratio is high
- given in combo with aspirin or tylenol
Methadone
- mu receptor
- given orally, has slow onset & long duration
- for addiction (heroin) and chronic pain
Meperidine
- mu receptor
- used in labor
- fast onset, short duration
- never give with an MAOI
Fentanyl
- mu receptor
- for general anesthesia & post-op pain
- rapid & brief action
Pentazocine
- kappa receptor
- partial agonist at mu receptor
- less respiratory despression than morphine
Buprenorphine
- high affinity for mu receptor, but acts as a partial agonist
- antagonist at kappa receptor
- never produces a high
- used for detox (heroin)
Naloxone
- competitive inhibitor of mu and kappa receptors
- given IV, rapid effect
- for diagnosis & treatment of overdose
Naltrexone
- competitive inhibitor of mu and kappa receptors
- given orally, longer lasting than Naloxone
- treatment for opioid addiciton
Dextromethorphan
- structurally related to codeine
- produces no analgesic effect
- produces antitussive effect
- suggests that codeine also acts on non-opioid receptors
Levodopa
- converted to DA by AAAD
- absorbed in the proximal small intestine via LNAA
- LNAA is saturable, L-dopa must compete with dietary amino acids
- AAAD and COMT are high in the periphery
Carbidopa
- given with L-dopa as Sinemet
- inhibits AAAD, but does not cross the BBB
Bromocriptine
- DA agonist, D2 & D3
- ergot derivative
Pramipexole
- DA agonist, D2 & D3
- non-ergot derivative
Amantadine
- causes DA release
- blocks NMDA receptors
- anticholinergic-like effects
- often the first treatment for PD
Selegiline
- selective MAOB inhibitor
- worsens L-dopa induced dyskinesias
Entacopone
- reversible COMT inhibitor
- only acts peripherally
- used for wearing-off effects, not as initial therapy
Tolcapone
- reversible COMT inhibitor
- acts peripherally & centrally
- rarely used because of hepatotoxicity
Antithymocytic Ig
- polyclonal Abs against T cell Ags
- lysis and phagocytosis of T cells
- used for induction/rescue therapy, GVHD, aplastic anemia
- may cause malignancies
OKT3
- mouse monoclonal Ab against CD3 on T cells
- may cause flu-like symptoms or malignancies
- used for acute rejection
Basiliximab
- chimeric monoclonal Ab against CD25 (IL2R alpha-chain)
- specific for T cells activated by IL2
- used for acute rejection
Daclizumab
- humanized monoclonal Ab against CD25 Tal subunit
- used for acute rejection
Cyclosporin
- inhibits calcineurin, blocks IL2 production (and others)
- used for graft rejection, GVHD & autoimmune diseases
- commonly causes nephrotoxicity
- can cause hirsutism & gingival hyperplasia
Tacrolimus
- binds FKBPs to inhibit calcineurin
- macrolide lactone
- used for prophylaxis for liver transplant
- does not cause hirsutism or gingival hyperplasia
Mycophenolate mofetil
- blocks guanosine synthesis which stops T & B cell proliferation
- noncompetitive, reversible
- prophylaxis for renal transplant
- may cause malignancies
Azathioprine
- inhibits guanosine synthesis which stops T & B cell proliferation
- nonspecific, competitive inhibitor
Sirolimus
- mTOR inhibitor, blocks T cell proliferation by stopping G1 to S transition
- macrolide lactone
- prophylaxis for renal transplant
Corticosteroids (prednisone)
- blocks IL1 release from macrophages to stop lymphocyte proliferation