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39 Cards in this Set
- Front
- Back
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DOC for RA?
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ASA
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DOC for osteo?
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tylenol
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tx for ASA toxicity?
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to increase urine pH:
IV fluids dialysis correct acid/base/electrolyte disturbances |
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DOC for trigeminal neuralgias?
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gabapentin
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regimen for p with diabetic peripheral neuropathy?
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gabapentin 15mg q PM
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p is taking ibuprophen for minor pain. pain then persists to step 2 "mild to moderate". what drug will you add?
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codeine
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what is the reccommended dose for calcitonin?
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50-100 IU sc/im.
give with calcium |
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your patient has been on calcitonin 100 IU x 6 months. what is the next step?
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D/C calcitonin after 6 months and try a biphosphanate (fosamax)
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MOA of calcitonin?
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inhibit osteoclastic bone reabsorption
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MOA of biphosphanates?
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inhibit osteoclastic bone resorption
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loss of bony tissue resulting in bones that are brittle and liable to fracture?
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osteoporosis
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what is the MC treatment for osteoporosis?
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biphosphanates
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what is the MC fracture?
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hip
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when do you start osteoporosis treatment?
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>40 c H/O fractures
post menopausal <65 with risk factors |
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thromboxanes, leukotrienes and prostaglandins are all synthesized from?
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arachidonic acid
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what converts arachidonic acid to prostaglandins and thromboxane?
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the enzyme cyclooxygenase
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where in the inflammation pathway do NSAIDS work?
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prostaglandins
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where does ASA work?
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on COX 1: inhibits TXa2
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what are the 3 main functions of ASA?
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anti inflammatory
analgesic antipyretic |
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at toxic/high levels of ASA what effects will it cause in relation to respiration?
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hyperventilation and respiratory alkalosis
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how do you correct ASA overdose?
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hCO3
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what are the adverse effects of ASA?
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GI bleed
prolongs bleeding time hypersensitivity rxn due to inhibition of leukotrienes |
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examples of non-opiote treatments?
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ASA
ibuprophen naproxen |
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what is the DOC in a gouty arthritis attack?
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indomethicin
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what are the adverse effects of indomethacin?
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GI
acute pancreatitis neutropenia thrombocytopenia allergic reactions |
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what drug is used to close PDA to avoid surgery in neonates?
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indomethacin
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where is indomethacin metabolized?
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in the liver, excreted in urine and bile
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patients who have a true ASA allergy are also not able to tolerate???
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KEtoralac (toradol)
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what drug is very similar to ASA, has equal anti-inflammatory potency and has the same ADE's as ASA?
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ibuprofen: motrin , advil, nuprin
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this drug is indicated in patients with severe acute pain and is the only IV NSAID but is contraindicated in the elderly?
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toradol
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what is the max dose for toradol?
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40mg PO qd
120mg IV QD |
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if you are allergic to aspirin then technically you are also allergic to???
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toradol
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what is the only COX 2 inhibitor available?
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celebrex 200mg
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what is celebrex used for?
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anti-inflamm
analgesic antipyretic |
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what are the indicated uses for celebrex
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Osteoarthritis
RA |
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what are the adverse effects of cox2 inhibitors?
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GI: n/v/d
edema |
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what is your alternative treatment for a patient who is allergic to NSAIDS and has liver failure?
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ultram with a low dose of APAP (tylenol) if necessary
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your patient is currently taking the max dose of tylenol of 4g QD. his cardiologist just informed you that he will be starting to take coumadin. what is your next step?
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cut tylenol dose in half since both meds are metabolized by the liver.
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what are the indicated uses for tylenol?
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reduce pain and fever, headache, reduce fever in viral infections
inhibits PG in the CNS |
