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24 Cards in this Set
- Front
- Back
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Polyene Antibiotics:
Amphotericin B Nystatin |
Binds to Egesterol, causes release of cytoplasmic contents
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Azole Derivatives:
Itraconazole Fluconazole Voriconazole Ketoconazole Clotrimazole |
inhibit 14a demethylase, blocking conversion of lanesterol to egesterol
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Allyamines:
Naftifine Terbinafine |
inhibit squalene monooxygenase
squalene cant be converted to lanesterol |
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Echinocandins:
Caspofungin Anidulafungin |
inhibits B(1,3)-D-glucans in cell wall, decreasing its strength
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Other Antifungals:
Flucytosine |
disrupts protein and DNA synthesis
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Other Antifungals:
Griseofulvin |
interacts with microtubules
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Anit-herpes:
Acyclovir Valacyclovir Penciclovir Famciclovir Ganciclovir Cidofovir Foscarnet |
competitively inhibits DNA polymerase
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Anti-Influenza A:
Amantadine Rimantadine |
prevents uncoating of influenza particles
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Anti-Influenza A&B:
Oseltmivir Zanamivir |
inhibits neuroaminidase, virions cant be released from infected cell
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Anti-Hepatitis:
Ribavirin |
inhibits synthesis of nucleic acid
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Anti-Hepatitis:
Interferons |
boosts host immune system
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HIV drugs, NRTI:
Zidovudine (AZT) Lamivudine Stavudine Didanosine Abacavir Emtricitabine Tenofovir |
competes for entry into cell, DNA chain termination
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HIV drugs, NNRTI:
Nevirapine Efavirenz |
Direct inhibition of reverse transcriptase
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HIV drugs, protease inhibitors:
Atazanivir Ritonavir Lopinavir |
causes production of immature viral particles
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HIV, entry inhibitors:
Enfuvirtide |
binds to GP41, blocks entry into cell
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Anti-Malarial, Blood Schizonticides:
Chloroquine |
concentrates in food vacuole, causes increase in Heme which leads to lysis of the RBC and parasite
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Metronidazole
Tinidazole |
reduces nitro group, causes toxic FR that damages DNA and proteins
Amebiasis and Giardiasis |
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Iodoquinol
Paromomycin Sulfate Diloxanide Furoate |
unkown MOA, kills cyst only
Amebiasis |
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Nitazoxanide
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inhibits pyruvate pathway, reduces energy available
Giardiasis in kids |
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Suramin
Melarsoprol |
inhibits pyruvate kinase, decreased ATP synthesis
East African sleep sickness |
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Pentamidine
Eflornithine |
Inhibits ornithine decarboxylase
West African sleep sickness |
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Nifurtimox
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O2 radicals that are toxic
American Chagas disease |
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Sodium Stibogluconate
Miltefosine Amphotericin B |
unknown MOA
Leishmaniasis |
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Albendazole
Mebendazole |
inhibits Microtubule synthesis
nematodes |
