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41 Cards in this Set
- Front
- Back
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Cyclophosphamide
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Alkylating Agent-physical cross link of DNA
CLL |
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Carumstine
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Alkylating Agent-physical cross link of DNA
Glioma |
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Procarbazine
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Alkylating Agent-physical cross link of DNA
HL |
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Cisplatin
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Alkylating Agent-physical cross link of DNA
Ovarian, Testicular, Bladder |
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Methotrexate
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Folic Acid antagonist
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Mercaptopurine
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Purine Antagonist
ALL suppression AML and CML treatment |
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Cladribine
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Purine Antagonist
Hairy Cell and other Luekemias |
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Flurouracil
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Pyrimidine Antagonist- 2 DNA and 1 RNA block
Colorectal |
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Cabecitabine
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Pyrimidine Antagonist- 2 DNA and 1 RNA block
Breast |
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Cytarabine
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Pyrimidine Antagonist- 2 DNA and 1 RNA block
blocks in S-phase AML |
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Vinblastine
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Plant Alkoid-arrest mitosis
in metaphase HL and non, BRCA |
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Vincristine
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Plant Alkoid-arrest mitosis
in metaphase HL and non, Whilms and Ewings (kids), ALL |
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Etoposide
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Plant Alkoid-arrest mitosis
inhibit topimerase 2, blocks S-G2 Gastric, Germ Cell, Lung |
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Topotecan
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Plant Alkoid-arrest mitosis
inhibits topimerase 1 Ovarian (after Cisplatin) |
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Paclitaxel
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Plant Alkoid-arrest mitosis
increases polymerization of MT Solid |
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Doxirubicin
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Antibiotics
inhibit topimerase 2 bind DNA, bind cell membrane, generate ROS Solid and Hematoligic |
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Daunorubicin
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Antibiotics
inhibit topimerase 2 bind DNA, bind cell membrane, generate ROS AML |
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Bleomycin
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Antibiotics
stuck in G2 phase |
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Mitomycin
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Antibiotics
crosslink w/ DNA Breast (w/ vincristine) |
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Dactinomycin
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Antibiotics
inhibit RNA synthesis Rhabdomyosarcoma and Wilms (kids) |
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Tamoxifen
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Steroids
binds estrogen receptor Breast |
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Flutamide
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Steroids
binds androgen receptor Prostate |
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Leuprolide
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Hormone
GnRH analog, initial increase of LH and FSH leads to desensitization of R, decrease testosterone synthesis Prostate |
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Anastrozole
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Aromatase Inhibitor
blocks conversion of androgens to estrogen metastatic BRCA postmenopausal |
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Exemestane
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Aromatase Inhibitor
irreversible inhibitor |
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Imatinib
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inhibits oncoprotein tyrosine kinase
CML and GI |
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Asparaginase
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prevents utilization of Asparginine
ALL in kids |
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Sorafenib
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inhibits kinases used in cell growth
renen cell carcinoma |
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Nelarabine
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induces apoptosis
Lymphoblastic leukemia |
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Lenalidomide
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enhances T cells and NK cells
Myelodysplastic syndrome |
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Prednisone
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glucocoricoid-interferes with cell cycle
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Cyclosporine
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inhibits Calcineurin
prevents rejection after transplant |
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Tacrolimus
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inhibits immunophilin
prevents rejection after transplant |
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Siromilus
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synergistic with cyclosporin
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Interferon A and B
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activate NK cells
A and B:melanoma and renal cell A: hep B and C B: MS |
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Mycophenolate Mofetil
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inhibits purine synthesis
increased efficacy in graft survival |
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Rho (D) antibody
(anti-d antibody) |
hemolytic disease of newborn
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Trastizumab
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HER-2
breast cancer w/ HER-2 neu receptor |
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Rituximab
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binds CD20 and malignant B cells
Follicular B cell non-HL |
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Palivizumab
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binds fusion protein of RSV
neonates at risk for RSV |
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Abatacept
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binds CD80 and CD86 (immunosupressant)
RA |
