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9 Cards in this Set
- Front
- Back
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Oral anticoagulants that inhibit the synthesis of coagulation factors
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Warfarin: Vit K agonist, inhibits factors II, VII, IX, and X
Dicumarol: same |
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Oral anticoagulants that inactivate coagulation factors: Indirect
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Heparin: binds and activates AT-III, immediately anticoagulating
give IV or subQ, not oral or IM (cant cross cell membrane) mostly affects Xa |
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types of heparin
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Enoxaparin- indirect; LMW
Dalteparin- indirect; LMW Fondaparinux- indirect, synthetic Unfractionated-increases interaction with thrombin and Xa |
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Oral anticoagulants that inactivate coagulation factors: Direct
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Hirudin-
Bivalirudin Lepirudin |
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Antiplatelet drugs: receptor blockers
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Abciximab: blocks GPIIb/IIIa receptor
Tirofiban: blocks GPIIb/IIIa receptor Eptifibatide: blocks GPIIb/IIIa receptor |
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Aspirin
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inhibits COX-1 in PLTs, inhibit TXA synthesis
prevents platelet formation |
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Clopidogrel
Ticlopidine |
block ADP receptors→decr Ca++ mobilization→reduce expression of GP receptors→inhibit PLT aggregation
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Fibrinolytic drugs: Tissue Plasminogen Activators
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Alteplase
Reteplase Tenecteplase Tx AMI, stroke, PE |
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Drugs to Tx bleeding
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Aminocaproic acid- inhibits plasminogen activation
Protamine sulfate- antagonized heparin Vitamin K |
