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57 Cards in this Set
- Front
- Back
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Eval tx thyroid ca, TSH human
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thyrotrpin
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• treat prostate ca, long ancting, inhibitory, (LH and FSH related)
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lueprolide
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• Recombinant TSH, for growth, turners – test with with arginine and GHRH
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somatotropin
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• Edited somatostatin, stop growth in gigant, acromegally GH related, G1 GPCR integration target IGF1
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octreotide
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• GH receptor antagonist, binds to but doesn’t cause downstream effx, causes HEPATITIS, against giganitis and Growth, IGF1 target
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pegvisomant
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side efx of PEGVISOMANT
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HEPATITIS
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• Against tumor of lactotropes, prolactinoma. Usually under dopa monior, give dopa agonist SE: POSTURAL HYPOTENSION, CARDIAC arrhythmias, start low dose, nausea vomit
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Bromocriptine
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SE of BROMOCRIPTINE
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POSTURAL HYPOTENSION
CARDIAC ARRYTHMIAS NAUSEA VOMIT |
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• Dopa agonist for prolactinoma, SE: Heart valve problem fibrotic heart valve
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Carbegoline
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SE CARBEGOLINE
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Heart valve fibrotic heart vlave
used for prolactinoma |
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• Adrenal insufficiency test, should raise cortisol, Gs, adynylyl cyclase p450.
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cosyntropin
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• For pple that cant conserve water, Diab insipidus, acts like vasopressin, puts aquaporins in.
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desmopressin
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• For Hypothyrpoidism T4, long in body, less side efx
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levothyroxne
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or hypothyroidism, T3 but short half life, causes jitters and hyperthyroid like sx
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liothyroxine
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• For graves dz, hyperthyroidism, iodide concentrates in thyroid, kills it, will be hypothyroid for life, no side efx cuz only in thyroid
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IOdine sodium I131
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• For hyperthyroidism, inhibits PTO not deoidiniase I. TETAROGENIC, AGRANULOCYTOSIS!!!
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methimazole
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methimazile SE
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AGRANULOCYTOSIS tetratogenic
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• For hyperthyroid pregnancy, stops PTO and deoidonase5I. Hepatotoxic and agranulocytosis!
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PTU
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SE for PTU
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agranulocytosis
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• Beta blocker used to fix jitter sx for hyperthyroidism = calm them down, high dose inhibits ID5 deoidonation
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propranalol
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• For thyroid storm, fallout, wolf caicoff efx, inhibits function
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iodine
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• mech not clear, inhibit iodide transport to thyroid, decreases pinocytosis from colloid and lumen. EFX similar to iodide, can be given in place of. Kills thyroid in a way
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lithium
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• blocks T4 to T3, helps in thyroid storm, SE: adrenal insufficiency, fluid disturbances, infection, hypertension, hyperglycemia, CATARACTS, osteoporosis, fat, hirtuism
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dexamethasone
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what is dexamethazone used for in thyroid dz
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stops deiodonization T4 to T3
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• Used for diagnosis of thyroid cancer , TSH, recombinant human, SAME THING AS THYROTROPIN
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Thyrogen
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3 categories of sex steroid
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androgen: testosterone, DHEA
- estrogen: estradiol, estrone, estriol - progestrine: progesterone |
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gonadotropins
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FSH, LH, hCG act through Gs coupled mechanism, LH and cCG act on same receptor
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risk of HRT in women
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- Venous thrombosis
- Endometrial cancer, breast cancer |
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contraindication for BC
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- Smokers
- Not with liver disease, breast ca, carcinoma - Progestrin increased libido, androgenic - Barbiturates and phenytoin interact and lead to failure - Penicillin and ABX eradicate intestinal flora needed for cycling |
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a. Fertility med for girls that cant ovulate, help men with low sperm counts produce more sperms. SE: Abdominal pain (severe), nausea, vomiting, and weight gain (rapid)
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Follitropin
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a. Recombinant LH, Infertility, SE: HA, N, ovarian hyperstimulation syndrome, breast pain, ovarian cysts; risk of multiple births, VASCULAR SX
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Leutropin
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a. Cant give Oral, 1st pass metabolism too high- basically TESTASTERONE
b. For testosterone replacement therapy in males hypogonadism c. SE: gynacomastia due to testosterone going to estrogen, POLYCYTHEMIA, prostate, infection dry skin Edema; virilization in females and prepubertal males; feminizing e.g., gynecomastia after conversion to estrogens by aromatase activity |
testasterone cypionate
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4. Testosterone enathate
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5. Testosterone undecanoate
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a. ANDROGEN SYNTESIS INHIBITOR Antifungal, inhibits p450 that acts in steroid formation. Salvage with prednisone. Side efx p450 and adrenal insufficiencty, hepatotox, nausea
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ketonidazole
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a. Steroid 5 alpha-reductase inhibitor, decreases conversion of testaterone to DHEA for BPH and Androgenic alopecia in men , SE: sexual dysfunction
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finasteride
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a. Steroid 5 alpha-reductase inhibitor, ANTI ANDROGEN test-x-> DHEA, use for BPH SE:sexual dysfunction
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duosteride
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a. Steroidal androgen receptor antagonist // Blocks progesterone and mineralocorticoid receptors, used for hirtuism, hypertension and heart failure
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spironolactone
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a. Pure non steroidal androgen receptor antagonist, used to treat PROSTATE CANCER and hirtuism, SE: nausea has to be given with LEUPROLIDE GnRH agonist for suppressing LH and FSH activity
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flutomide
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a. Non steroidal androgen receptor antagonist used for tx of prostate ca has to be used with leurpolide – SE: HEPATOTOXICITY, nausea
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bicalutamide
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a. Hormone replacement of estrogen, also ovarian problems, hypogonadism, SE: HTN, Throbolitic efx, Gallbladder DZ!!! Risk for breast ca.
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estradiol
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a. Same as estadiol only from pregnant mare urine…
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conjugated equine estogen
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a. Tx infertility by negative feedback to FSH and LH increasing them/ inducing ovulation , estrogen antagonist
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clomiphen
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a. Oral, long half life 7d, metabolytes more active CYP3a4 CYP2d6, for estrogen receptor positive breast ca. antagonist for CNS and BREAST but AGONIST in bone, uterus and lipid metabolism
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tamoxifen
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a. SERM, prevents osteoporosis and BREAST CA, mixed function estrogen receptor agonist antagonist, agonist in bone and CV sys, antagonist in Uterus and Breast
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Rolexefin
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a. PURE ANTAGONIST SERM, no agonist activity like tamoxifen and raloxifene, used for breast cancer
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Fulvestrant
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a. Type 1 based aromatase inhibitor, steroid based, covalent adduct to protein first like of ER and Breast Ca, SE: osteoporosis and HEPATOTOXICITY In POSTMENAPAUSAL WOMEN!!!
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examestane
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a. first like of ER and Breast Ca, SE: osteoporosis and HEPATOTOXICITY
b. Anastrozole inhibits the enzyme aromatase, which is responsible for converting androgens to estrogens. Anastrozole binds reversibly to the aromatase enzyme through competitive inhibition. |
anastozole
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type 2 azole based aromatase inhibitor
a. first like of ER and Breast Ca, SE: osteoporosis and HEPATOTOXICITY b. competitive, reversible binding to the heme of its cytochrome P450 unit |
letrozole
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a. Primary natural progestin in mammals, undergoes fisrt pass – esters made so can take oral
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micronized progesterone
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a. Most simple progesterone derivative, endometrial hyperplasiea, HRT, bleeding, suppress gonadotropins SE: bloating, mood swings, depression, vaginal dryness
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methodroxypregesterone acetate
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ESTRANE –most (Micronor, NorQD)
a. Progesterone only BC pill, androgenic efx most closely related AR |
norethindrone
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GONANES (DEPO)
a. Improved progestational selectivity and less androgenic activity, GONANES |
levonogesterel
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a. GONANES, IMPROVED progestational selectivity and less androgenic efx
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desogestrel
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a. Glucocorticoid against inflammation, also used in deiodo T4-T3
b. Anti inflammatory anti emetic glucocorticoid NO MINERALOCORTICOID EFX c. Use VOMIT adrenal insufficiency, inflammation, immunosippresion d. Adverse : hHTN, hyperglycemia, myopathy, cataracts, osteoporosis |
dexamethazone
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a. Antiinflamatory, immunosuppressant, glucocorticoid LIKE CORTISOL
b. 3-4 x potent then cortisol, inflammation Autoimmune HEP, organ translapnt. c. SE: adrenal insufficiency after withdrawl, fluid electrolytes infection, cataracts |
prednisone
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a. Antiinflamatory, meneralocorticoid for adrenal insufficiency, and inflammation. SE: adreanal insuff after withdwal, infection, HTN etc LIKE CORTISOL
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hydropcortisone
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a. MINERALOCORTICOID like ALDOSTERONE!!! Mech substitute for aldosterone in adrenal insufficiency and salt wasting
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fludrocortisone
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