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13 Cards in this Set

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  • Back
Therapy of any viral infections is aimed at _
Arresting or delaying replication of the virus
2 classes of antiviral drugs
1. HSV and CMV
2. HIV/AIDS
How do inhibitors of viral nucleic acid act
- Act as ANTIMETABOLITES because they are structurally similar to PURINE or PYRIMIDINE
- Drug undergoes PHOSPHORYLATION by host cell kinases
Two drugs are EXCEPTION to phosphorylation - phosphorylated by viral kinases
ACYCLOVIR
GANCICLOVIR
Acyclovir MOA
Phosphorylation by TK - thymidine kinase
Gancyclovir MOA
Phosphorylation by CMV protein kinase (UL97)
Spectrum of Acyclovir
Herpes simplex
Epstein Barr
Varicella Zoster
Resistance to acyclovir
Can develop in HSV or VZV via alteration in either viral THYMIDINE KINASE or VIRAL POLYMERASE
Clinical use of acyclovir
- Mucocutaneous herpetic lesions
- Genital herpes lesions
- Prophylactic in AIDS and other immunocompromised patients
Side effects of Acyclovir
Delirium
Tremor
Seizures
Hypotension
Nephrotoxicity
Valacyclovir compared to acyclovir
Valacyclovir is the ester of acyclovir - LONGER LASTING
Gancyclovir is against _
CMV
Gancyclovir adverse effects
Leukopenia
Thrombocytopenia
Mucositis
Hepatic dysfunction
Seizures